摘要
[目的]研究麝香、冰片等组成的醒脑静对神经细胞的保护作用。[方法]利用原代培养的大鼠大脑皮层神经细胞,观察醒脑静对抗谷氨酸(10μmol·L-1,3h)对脑细胞的兴奋毒性作用。[结果]醒脑静能减少谷氨酸所造成的细胞内乳酸脱氢酶漏出量,减轻细胞的形态学改变。[结论]醒脑静能够对抗谷氨酸介导的兴奋性毒性,对培养的大鼠大脑皮层细胞具有保护作用。
[Objective] To study the protective effect of Xing Nao Jing (XNJ) on cultured cortical neurons in rats. [Methods] Primary cultured cortical neurons were applied to observe the effect of XNJ in counteracting the excitotoxicity ofglutamic acid. [Results] XNJ decreased the release of intracellular lactic dehydrogenase induced by glutamic acid and reduced the histological changes of cultured cortical neurons. [Conclusion] XNJ can counteract the excitotoxicity of glutamic acid and protect cultured cortical neurons in rats.
出处
《广州中医药大学学报》
CAS
2002年第2期125-126,共2页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
醒脑静
药理学
神经元
药物作用
麝香
冰片
中药
XING NAO JING/phamiacology
NEURONS/drug effects
MOSCHUS/pharmacology
BORNEOLUM SYNTHETICUM /pharmacology
