摘要
目的 :观察全身炎症反应综合征 (SIRS)患者空腹血糖 (FBG)、胰岛素 (FINS)和肿瘤坏死因子 α(TNF α)的变化。方法 :符合SIRS诊断 32例禁食 12h ,于次晨空腹抽取肘静脉血 5ml,测定FBG、FINS和TNF α ,并测算胰岛素敏感指数 (ISI)。结果 :SIRS组和对照组相比FBG差异无显著性 (P >0 .0 5 ) ,FINS、TNF α显著高于对照组 (P <0 .0 1) ,而ISI显著低于对照组 (P <0 .0 1) ,说明SIRS患者存在胰岛素抵抗 (IR)。器官功能不全的患者IR更为严重 ,FINS、TNF α显著高于器官功能正常组 (P <0 .0 1) ,ISI显著低于器官功能正常组 (P <0 .0 5 )。结论 :IR与SIRS的发生。
Objective: To observe the change of fasting blood sugar (FBS),insulin and tumor necrosis factor in patients with systemic inflammatory response syndrome (SIRS). Methods: 32 patients coincided with SIRS were studied,after 12 hours fasting,5 ml blood was drawn from cubital vein for determination of FBS,Insulin and tumor necrosis factor α(TNF α) insulin sensitive index(ISI) was calculated. Results: FBS was not obviously different between SIRS group and control group,insulin and TNF α were obviously higher in the SIRS group than that in the control group. This indicated that patients with SIRS had insulin resistance (IR). Patients with organ malfunction showed more severe insulin resistance,insulin and TNF α were more higher in the organ malfunction group than that in the normal function group, but ISI was much lower in the organ malfunction group than in the normal organ function group. Conclusion: Insulin resistance was associated with the occurrence, development and prognosis of SIRS.
出处
《内科急危重症杂志》
2002年第2期85-86,共2页
Journal of Critical Care In Internal Medicine
关键词
全身炎症反应综合征
胰岛素抵抗
肿瘤坏死因子-Α
Systemic inflammatory response syndrome Insulin resistance Tumor necrosis factor α
