摘要
目的观察胰岛素泵强化治疗对降糖药继发性失效(SFS)的2型糖尿病患者炎性细胞因子及胰岛功能的影响。方法 50例SFS的2型糖尿病患者停用口服降糖药,改用胰岛素泵强化治疗2周,观察治疗前后的空腹血糖、餐后2-h血糖、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的变化。结果强化治疗后,患者空腹血糖、餐后2-h血糖、HOMA-IR、TNF-α、IL-6水平均较治疗前明显下降(P<0.05),HOMA-β较治疗前明显增高(P<0.05)。结论胰岛素泵强化治疗可减轻SFS的2型糖尿病患者胰岛素抵抗,改善胰岛β细胞功能,降低机体炎性因子水平。
Objective To observe the effects of intensive insulin analogues therapy on function of pancreatic β-cell,inflammatory cell factor in the sulfonylurea secondary failure（SFS） patients with type 2 diabetes mellitus（T2DM）.Methods The intensive treatment with insulin pump instead of oral glucose-lowering medications was performed in 50 T2DM cases with SFS.The intensive treatment lasted fo two weeks and fasting blood glucose（FBG）,islet function and serum levels of TNF-α and IL-6 were examined before and after treatment.Results After intensive therapy,FBG,postprandial 2-h BG,insulin resistance index（HOMA-IR）,TNF-α and IL-6 were lower,but insulin secretion index（HOMA-β） was higher,after treatment than those before（P0.05）.Conclusion Insulin intensive therapy can reduce insulin resistance,improve beta cell function,decrease the levels of the inflammation factors in the T2DM patients with SFS.
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第3期296-297,共2页
Jiangsu Medical Journal
关键词
2型糖尿病
胰岛素抵抗
胰岛素泵
Type 2 diabetes mellitus
Insulin resistance
Insulin pump
