摘要
目的 :探讨表皮生长因子 (EGF)、白细胞介素 6 (IL 6 )、肿瘤坏死因子 α(TNF α)等 3种细胞因子的含量与肺癌及其预后的关系。方法 :取明确诊断为肺癌的患者术前和术后血清以及手术中肺癌及肺周围组织标本进行细胞因子的检测 ,同时进行该组患者肺癌复发和转移的观察。结果 :TNF α在肺癌组织与肺周边组织中含量无明显变化 ,EGF在癌组织中存活组与死亡组比较其含量差异有显著性 (P <0 .0 5 ) ,IL 6在肺组织中存活组与死亡组比较其含量差异有显著性 (P <0 .0 5 )。结论 :EGF、IL 6的变化与肺癌患者的生存期有一定关系 ,而TNF
Purpose:To study the relationship between the level of EGF,IL 6,TNF α and the survival of lung cancer pateints.Methods:To test the level of the cytofactors in serum of the patients ,before and after operation, and in the tissues of peripheral lung.Results:①The level of TNF α was not significantly changed in lung cancer and peripheral lung tissues. ②The level of EGF and IL 6 were considerably different in the patients between those who died and those who survived ( P <0.05). Conclusions:The levels of EGF and IL 6 affect the survival of lung cancer patients, but the level of TNF αwas does not show positive relationship with this groups.
出处
《中国癌症杂志》
CAS
CSCD
2002年第3期237-238,268,共3页
China Oncology
