摘要
目的 探讨凝血酶原活动度 (PTA)、白球比值 (A/G)及胆固醇 (TC)与慢性乙型肝炎病情的关系。方法 采用日本产全自动血凝分析仪和日本产全自动生化分析仪检测慢性乙型肝炎轻度组病人 49例、中度组病人 42例和重度组病人 3 3例PTA、A/G及TC水平。结果 PTA和A/G随着慢性乙型肝炎病情程度加重逐渐下降 ,各组间差异非常显著 (P <0 0 1) ,重度组下降最为明显 ,明显低于中度组 (P <0 0 0 1) ,TC在慢性乙型肝炎轻度组、中度组并无下降 ,两组间也无显著差异 (P >0 0 5 ) ,重度组则下降明显 ,与轻度组、中度组存在显著差异 (P <0 0 0 1)。结论 PTA较TC能更好地反映肝脏的合成功能 ,能更准确地反映慢性乙型肝炎的病情。
Aim To explore the possible relationship between prothrombin activity (PTA),ratio of serum albumin to globulin (A/G),total cholesterol(TC) and the state of chronic hepatitis B (CHB).Methods The levels of PTA of 124 patients with CHB (including 49 mild cases,42 moderate cases and 33 severe cases) were tested by automated blood coagulation analyzer (Sysmex CA 500,Japan) and A/G,TC by automated biochemical analyzer (Beckman CX 7,Japan).Results With the aggrevation of CHB,the level of PTA and A/G decreased significantly in all groups ( P <0.01),and decreased most among the severe cases,which significantly lower than that of moderate cases ( P <0.001).Meanwhile,the level of TC among mild and moderate cases didn′t decline,and no significant difference could be observed between the two groups ( P >0.05).But among severe cases,the level of TC dropped obviously and was significantly different from that of the other two groups ( P <0 001).Conclusions The index of PTA can reflect the synthetic function of liver more accurately than TC,and can be further used to assess the severity of CHB.The index of A/G can be as effective as PTA.
出处
《胃肠病学和肝病学杂志》
CAS
2002年第2期160-162,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
慢性乙型肝炎
凝血酶原活动度
白球比值
胆固醇
Chronic hepatitis B Prothrombin activity Ratio of albumin to globulin Total cholesterol
