摘要
目的 :研究H2 受体拮抗剂 (H2 RA)三联疗法与质子泵抑制剂 (PPI)三联疗法及其 1周与 2周疗法对根除幽门螺杆菌 (H .pylori,Hp)的效果。 方法 :1 2 8例Hp阳性的胃炎和十二指肠溃疡患者随机分成H2 RA三联组和PPI三联组。H2 RA三联组 (法莫替丁 2 0mg ,bid +阿莫西林 1 .0g,bid +甲硝唑 0 .4g ,bid ,疗程 1或 2周 ) ,PPI三联组 (奥美拉唑 2 0mg ,bid +阿莫西林 1 .0 g ,bid +甲硝唑 0 .4g ,bid ,疗程 1或 2周 )。疗程结束后 4周复查Hp。 结果 :H2 RA三联与PPI三联疗法Hp根除率 1周分别为 56 .0 %和 76 .9% ;2周为 81 .6 %和 82 .1 %。 结论 :H2 RA三联疗法 2周的Hp根除率明显高于 1周Hp根除率 (P <0 .0 5) ,但PPI三联疗法 1周与 2周无统计学差异 (P >0 .0 5)。H2
Objective:To compare the efficacies of H 2RA and PPI based triple regimens in the treatment of Helicobacter pylori (Hp) infection for 1 week or 2 week.Methods:128 patients with Hp associated gastritis and peptic ulcer were randomly divided into H 2RA triple regimens(famotidine 20mg,bid+amoxicillin 1.0g,bid+metronidazole 0.4g,bid for 1 week or 2 week)and PPI triple regimens(omeprazole 20mg,bid+amoxicillin 1.0g,bid+metronidazole 0.4g,bid for 1 week or 2 week).The efficacies were determined by gastroendoscopy or JC13,D,Z UBT at least 4 weeks after antibiotics therapies.Results:The eradication rate of Hp for 1 week H 2RA and PPI triple regimens were 56.0% and 76.9%,and that for 2 week H 2RA and PPI triple regimens were 81.6% and 82.1%.Conclusion:The eradication rate of Hp in H 2RA 2 week regimen was significantly higher than that in 1 week regimens( P <0.05),but no significant difference occurred between PPI 1 week and PPI 2 week regimens.H 2RA and PPI triple regimens proved equally effective in both Hp eradication. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2002年第6期474-476,共3页
Chinese Journal of New Drugs
