摘要
目的 探讨糖皮质激素受体变化在烧伤后应激性胃粘膜损害中的作用。 方法 观察大鼠严重烧伤后不同时相胃粘膜组织糖皮质激素受体的动态变化及胃粘膜损伤情况。 结果 伤后6h皮质醇含量明显升高 ,12h达高峰 (P <0 .0 5～ 0 .0 1) ,而胃粘膜细胞胞浆内糖皮质激素受体水平显著下降 (P <0 .0 5～ 0 .0 1) ,胃粘膜损伤指数于伤后 6、12、2 4、4 8h显著增加 (P <0 .0 5～ 0 .0 1)。
Objective To investigate the role of the change in glucocorticoid receptor in stress induced gastric ulcer in severely burned rats. Methods Wistar rats inflicted with 30% TBSA full thickness burn were employed as the model. The dynamic postburn change in the glucocorticoid receptor in gastric mucosal tissue and gastric mucosal injury (injury index) were observed. Results The gastric mucosal cortisol content increased as of 3 postburn hours (PBHs) and peaked at 12 PBHs. But the cytoplasmic glucocorticoid receptor content in the gastric mucosal cells decreased evidently. In addition, the gastric mucosal injury index increased obviously at 12 and 24 PBHs. Conclusion The decrease of gastric mucosal cytoplasmic glucocorticoid receptor content might be closely related to the stress induced gastric mucosal injury.
出处
《中华烧伤杂志》
CAS
CSCD
2002年第3期163-165,共3页
Chinese Journal of Burns
