摘要
观察黄芪注射液 (HQI)对四氯化碳 (CCl4)所致肝损伤的保护作用。采用CCl4所致肝损伤模型 ,并测定功能 ,肝组织学检查及肝组织匀浆脂质过氧化。结果为 ,CCl4模型组小鼠血清GPT为 (94 5 .7±14 6 .1)U/ 10 0mL ,显著高于正常对照组 (P <0 .0 1)。HQI低、高剂量组的血清GPT分别为 (5 76 .3±97.4 )U/ 10 0mL和 (5 18 6± 78.8)U/ 10 0mL ,均显著低于模型组 (P <0 .0 1)。HQI治疗组肝组织MDA浓度显著低于模型组 ,病理学损伤减轻。结论为 ,注射 3g/kg～ 10g/kgHQI可减轻CCl4引起的小鼠肝脏损伤。本实验结果提示 。
The present experiments were designed to study the protective effects of astragalus injection (Huang Qi injection HQI.) on carbon tetrachloride-induced mouse liver lesion, and to study effect of HQI on production of lipid hyperoxides. HQI-treated mice had a significantly lower level GPT and lower concentration of liver MDA at 24 hours after lip carbon tetrachloride. Histological examination revealed that HQI-treated mice liver had less necrosis focus. The present results indicate that HQI ameliorates carbon tetrachloride-induced mouse liver lesion at doses of 3?g/kg-10?g/kg.
出处
《太原科技》
2002年第3期26-27,共2页
Taiyuan Science and Technology
