摘要
目的 :研究补肾活血中药天鼓冲剂对药物性耳聋的干预作用。方法 :对 12 0例接受听觉语言康复训练的药物性耳聋患儿 ,分别用天鼓冲剂和安慰剂治疗 ,对比疗效 ;实验研究将 6 8只豚鼠分为天鼓冲剂预防组、治疗组和相应的正常对照、模型对照组 ,造模以皮下注射庆大霉素 12 5mg/kg/d× 12 ,观察中药对听功能及耳蜗形态学变化的影响。结果 :与安慰剂组对照 ,天鼓冲剂治疗组纯音听阈明显降低 (P <0 0 5 ) ,言语分辨率明显提高(P <0 0 1) ;预防组和治疗组豚鼠ABR阈值较相应模型组均明显减轻 (P <0 0 5 )。结论 :天鼓冲剂对药物性耳聋具有明显的防治作用 ,中药干预是提高聋儿康复效果的有效方法之一。
Objective:To investigate the intervenient effect of tiangu granule on deafness caused by the aminoglycoside antibiotics . Methods:120 patients were treated with tiangu granule or comfortable agent to compare the curative effects.68 guinea pigs were randomly divided into preventive group,curative group and corresponding normal,model control groups to observe the influence of tiangu granule on the auditory function and the changes of cochlear morphology. Results:Compared with the patients treated with comfortable agent,those with tiangu granule had obviously lower pure tone threshold (P<0 05) and higher speech recognition score(P<0.01).The guinea pigs of preventive group and curative group showed significantly lower ABR threshold and slighter lesion of cochlear hair cells than those of the corresponding model groups(P<0 05) Conclusion: Tiangu granule has obvious preventive and curative effects on the deafness caused by the aminoglycoside antibiotics .
出处
《中国中医药科技》
CAS
2002年第3期131-132,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
国家中医药管理局资助课题NO 97Z0 2 7
