摘要
目的 观察三七总皂苷 (PNS)对大鼠烧伤后心肌力学损害的防治作用。方法 70只wister大鼠随机分成伤前对照组、30 %Ⅲ°烧伤组和 30 %Ⅲ°烧伤后PNS治疗组 ,分别测定烧伤和治疗组伤后 1、3、6、12、2 4h以及伤前对照组的心肌力学参数 ,观察其心肌组织形态学变化。结果 同烧伤组比较 ,PNS治疗组的心肌力学各项指标在烧伤后 12h开始显著改善 ,心肌形态学改变较烧伤组明显减轻。结论 PNS具有明显改善严重烧伤大鼠心肌力学和减轻心肌损害的作用。
Aim To clarify the prophylactic and therapeutic effects of Panax Notoginseng Saponins (PNS) on the myocardial mechanic damages in burned rats.Methods 70 Wistar rats were divided at random into 3 groups as burned (30% III°),group PNS (30% III°,treated by PNS), and group control.The myocardial mechanic parameters and the myocardial morphological changes of the 3 groups were investigated at 1,3,6,12 and 24h postburn.Results The myocardial morphological appearance and myocardial mechanic parameters were significantly improved in group PNS after 12 hours vs those of group burned.Conclusion PNS can significantly improve the myocardial mechanic parameters and relieve the myocardial damages in burned rats.
出处
《解放军药学学报》
CAS
2002年第3期157-160,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
国家重点基础研究发展规划项目
No .G19990 5 42 0 2
军队"十五"指令性课题
No.0 1L0 66
