摘要
目的探讨非酒精性脂肪肝与胰岛素抵抗的关系。方法 对符合B超诊断标准的非酒精性脂肪肝患者进行口服葡萄糖耐量试验、胰岛素和C肽释放试验 ,计算胰岛素敏感指数 (ISI) ,并以不嗜酒的健康人作为对照。结果 脂肪肝患者空腹和口服葡萄糖后各时点的血糖、胰岛素、C肽水平均高于对照组 (P<0.05或0.01) ,ISI值低于对照组 (P<0.01) ;但不同程度脂肪肝患者之间无差别 (P>0.05)。结论 脂肪肝患者存在明显的胰岛素抵抗 。
Objective To explore the correlation of nonalcoholic fatty liver with insulin resistance.Methods The subjects were 85 patients with fatty liver diagnosed by B ultrasonic echograph,while the controls were 32 normal individuals.Oral glucose tolerance test(OGTT),insulin release test(IRT),c_peptide release test(CPRT) and insulin sensitivity index(ISI) were performed.Results Serum glucose,insulin levels,c_peptide levels at fasting and 0.5h,1h,2h,3h after glucose intake in the fatty liver patients were significantly higher and ISI was lower than that of controls(P<0.05～0.01).There was no significant difference among fatty liver patients with different degree(P>0.05).Conclusion Evident insulin resistance exsists in the patients with fatty liver,which suggests that insulin resistance may play a role in the pathogenesis of fatty liver.
出处
《浙江医学》
CAS
2002年第5期267-269,共3页
Zhejiang Medical Journal
