摘要
目的评价女性非酒精性脂肪性肝病(NAFLD)胰岛β细胞功能和胰岛素抵抗。方法应用高葡萄糖钳夹技术检测了9例NAFLD和7例正常对照组胰岛β细胞功能和胰岛素敏感性,采用梯度回波化学位移MR I评估了肝脏同相(IP)像值和反相(OP)像值,并测定了皮下脂肪面积(SA)、内脏脂肪面积(VA)。结果NAFLD组空腹胰岛素(FINS)、胰岛素分泌第一时相(1Ph)、葡萄糖代谢清除率(GDR)、胰岛素敏感指数(ISI)低于正常对照组(P<0.05)。结论女性NAFLD患者存在早期胰岛功能损害和胰岛素抵抗。
Objective To evaluate β-cell function and insulin resistance in female patients with nonalcohohc fatty liver disease （NAFLD）. Methods The investigation used case control study. Nine patients with nonalcoholic fatty liver disease （NAFLD） and seven control subjects （C） were analyzed for β- cell function and insulin sensitivity by hyperglycemic clamp. All subjects were measured subcutaneous adipose areas（SA） ,visceral adipose areas（VA） ,liver in-phase（IP） and out-phase（OP） by MRI. Result The result showed the levels of fasting insulin （FINS） ,first phase insulin release（1Ph） ,glucose disposal rates（GDR） ,and insulin sensitivity index（ISI） were signifcanfly lower in NAFLD than those of C group （ P 〈 0.05 ）. Conclusion The result suggested that female patients of NAFLD existed early beta-cell dysfunction and insulin resistance.
出处
《临床内科杂志》
CAS
2006年第10期695-697,共3页
Journal of Clinical Internal Medicine
基金
上海市科技发展基金资助项目(044119707)
