摘要
目的 调查上海地区肺炎链球菌对红霉素、克林霉素的耐药率及红霉素耐药菌的耐药表型。方法 以琼脂稀释法测定 345株肺炎链球菌对红霉素、克林霉素的最低抑菌浓度 ,以双纸片法测定红霉素耐药菌的耐药表型。结果 肺炎链球菌对红霉素及克林霉素的耐药率分别为 5 3.0 %(183/ 345 )及 4 9.6 % (171/ 345 )。对红霉素耐药菌中 ,内在型耐药 (cMLS)占 90 .3% (15 9/ 176 ) ,诱导型耐药 (iMLS)占 5 .7% (10 / 176 ) ,M型耐药占 4 .0 % (7/ 176 )。结论 上海地区肺炎链球菌对红霉素的耐药率高 ,其耐药表型以cMLS为主。
Objective To investigate bacterial resistance of Streptococcus pneumoniae against erythromycin and clindamycin, and resistance phenotypes of erythromycin resistant S. pneumoniae. Methods The MICs of erythromycin and clindamycin against 345 strains of S. pneumoniae were tested with agar dilution method, the phenotypes of erythromycin resistant S. pneumoniae were detected by double disc test. Results The resistance rates of S. pneumoniae to erythromycin and clindamycin were 53.0%(183/345) and 49.6%(171/345), respectively. Among erythromycin resistant S. pneumoniae , the percentages of cMLS, iMLS and M phenotype were 90.3% (159/176), 5.7% (10/176) and 4.0%(7/176), respectively. Conclusions The resistance rate of S.pneumoniae against erythromycin is very high in Shanghai. The main phenotype is cMLS.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2002年第2期71-73,共3页
Chinese Journal of Infectious Diseases
关键词
肺炎链球菌
红霉素
克林霉素
药物耐受性
表型
Streptococcus pneumoniae
Erythromycin
Clindamycin
Drug tolerance
Phenotype
