摘要
目的 探讨肝细胞性肝癌 (HCC)组织内树突状细胞及淋巴细胞浸润的临床意义。方法 收集 1995年 1月～ 1996年 7月在本院接受肿瘤根治性切除术的 4 4例HCC患者的临床病理资料 ,采用免疫组织化学方法检测HCC组织内树突状细胞浸润的数目 ,同时评估淋巴细胞的浸润情况 ,分析两者与肝癌切除术后肿瘤复发时间及生存率之间的关系。 结果 发现肿瘤组织内树突状细胞数≥ 2 0、同时伴淋巴细胞浸润 (+)者 (A组 ,n =17)术后肿瘤复发时间显著晚于不同时具备上述两项条件者 (B组 ,n =2 7) ,两者复发的中位期分别为 2 1 6个月和 4 1个月 (U值 =10 5 5 ,P =0 0 0 9)。A组术后 1、3、4年生存率分别为 83 5 %、6 1 8%和 4 8 7% ,B组分别为 4 2 2 %、2 8 4 %和 2 3 0 % ,A组均显著高于B组 (Logrank =7 6 8,P =0 0 0 6 )。 结论 HCC组织内树突状细胞及淋巴细胞浸润情况与临床预后密切相关 。
Objective To explore the clinical significances of dendritic cells and lymphocytes infiltration in hepatocellular carcinoma(HCC) tissue. Methods Clinicopathological data were collected from 44 patients with HCC who had under/gone curative tumor resection in our hospital. Immunohistochemical staining was used to detect the infiltration of dendritic cells in the tumor tissue, and lymphocytes infiltration was assessed simultaneously. The correlation between the infiltration of dendritic cells and lymphocytes and postoperative tumor recurrence and survival rate was analyzed. Results Tumor recurrence was markedly late in patients with dendritic cells count≥20 and positive lymphocytes infiltration(group A, n =17) as compared with those who did not meet both criteria simultaneously(group B, n =27), with a median interval of 21 6 months for group A and 4 1months for group B( U value=105 5, P =0 009). The 1 , 3 , 4 year survival rates were significantly greater in group A than in group B; they were 83 5% vs. 42 2%, 61 8% vs. 28 4% and 48 7% vs. 23 0%, respectively(Log rank=7 68, P <0 01). Conclusion The infiltration of dendritic cells and lymphocytes in HCC tissue, as an independent prognostic factor, was closely related to postoperative prognosis.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2002年第5期336-338,I001,共4页
Chinese Journal of Surgery
基金
国家自然科学基金资助项目 (3 0 10 0 180 )
