摘要
目的 观察橡胶生产的职业暴露对作业工人淋巴细胞DNA损伤的影响。方法 应用彗星试验检测某橡胶厂 2 81名生产工人淋巴细胞DNA的损伤 ,以 90名管理人员为对照组。结果 生产工人的彗星矩 (TM )大于管理人员(1 77μm与 1 5 2 μm ,P =0 0 4) ,6个工种中以混合车间工人的TM值最大 ,其余依次为整理、压延、硫化和维修等组 ,管理人员组的TM值最小 (F =3 2 1,P =0 0 0 8)。吸烟 (P =0 0 12 )、饮酒 (P =0 0 13 )可使TM值显著增加。结论 橡胶生产的职业接触、吸烟可致淋巴细胞DNA损伤。
Objective To study the effects of exposure to rubber production on lymphocytic DNA damage in the workers.Methods With comet assay,lymphocytic damage in 281 production workers and 90 managerial workers of a rubber factory were examined for lymphocytic DNA damage.Results Tail moment(TM)in comet assay was greater in the production workers(1 77μm)than in the managerial workers(1 52μm),with a P value of 0 04,and the largest TM was observed in workers of the mixers,followed by the finishers,the calendering workers,vulcanizers and maintenance workers,and the smallest TM was seen in the managerial workers,with F of 3 21 and P value of 0 008.TM could be increased by smoking,adjusted for other covariates.Conclusions Occupational exposure in rubber production and smoking could cause lymphocytic DNA damage in the workers.
出处
《中国工业医学杂志》
CAS
北大核心
2002年第1期10-12,共3页
Chinese Journal of Industrial Medicine
基金
广东省科技厅资助
广州市卫生局资助 (编号 :98- 1 31 )
