摘要
目的 探讨升压治疗对局灶性脑缺血的保护作用及治疗时间窗。方法 采用大鼠局灶性脑缺血再灌注模型 ,30只大鼠随即分为 6组 :对照组、缺血即刻升压、缺血 1h升压、缺血 2h升压、缺血 3h升压、缺血 4h升压。观察血脑屏障破坏程度、脑梗死体积的情况。结果 缺血后 3h、4h升压后脑梗死体积与对照组分别为 4 0 9.96± 79.34mm3 、4 13.13± 6 8.14mm3 、4 10 .8± 87.6 9mm3 无统计学差异 (P >0 .0 5 ) ,且血脑屏障破坏程度明显大于对照组。结论 缺血 3h再灌注时 ,升压时间窗不超过 2h。
Objective To investigate the protective effects on temporary focal cerebral ischemia and therapeutic time window of induced hypertension. Methods Cerebral ischemia was induced in the temporary middle cerebral artery occlusion model. 30 rats were randomly divided into six groups as follows: control group, induced hypertension group during and after a 1h, 2h, 3h or 4h period of MCA occlusion. The size of infarction and the injured level of blood brain barrier were assessed. Results Infarct size of hypertension induced after 3h or 4h MCAO had no significant difference compared with control group ( 409.96 ± 79.34 mm 3、 413.13 ± 68.14 mm 3、 410.8 ± 87.69 mm 3 respectively, P > 0.05 ) and the injure of blood brain barrier was more marked than control group. Conclusion The therapeutic time window of induced hypertension is within after 2h after 3h ischemia.
出处
《卒中与神经疾病》
2002年第2期101-103,共3页
Stroke and Nervous Diseases
关键词
升压治疗
脑缺血
再灌注
升压
时间窗
Cerebral ischemia/reperfusion Hypertension Therapeutic time window
