摘要
目的 :研究脑血管药金森脑泰注射剂 (CBN)中葛根素在大鼠肝肾分布的药物动力学。方法 :取正常和脑缺血再灌大鼠行股静脉给药。采血和肝肾。HPLC测定葛根素含量。计算肝肾中葛根素含量变化。结果 :静脉给药后正常大鼠葛根素主要在肾脏分布。且分布较快。药后 15min分布达峰值 ,30min迅速下降。肝脏分布量少 ,但达峰时间及分布特点同肾脏。缺血再灌大鼠肝脏药物浓度明显升高。为正常鼠的 2倍强。肾脏达峰时间明显延迟为 30min。结论 :CBN中葛根素主要在肾脏分布。缺血再灌时经肾分布时间延迟。肝脏含量明显升高。生病理状态下肝肾二脏中葛根素存在着明显的药物动力学差异。
To study puerarin in CBN injection on the active distribution in rat's liver and kidney, CBN injection was given (iv,100mg/kg)by femoral vein on both normal and cerebral ischemia reperfusion rats,then the blood by abdominal aorta and the liver and kidney were collected, and then puerarin from them was prepared. The concentration of prerarin from the samples was determined by HPLC and the active distribution of puerarin in both liver and kidney was determined at last. Results showed puerarin distributed quickly in liver and kidney after iv CBN injection in normal rats. The peak-time of concentration in kidney was at 15 min after injection, and downwards quickly at 30 min. In model rats, the concentration in liver was higher than normal rat 2 times as many as. The peak time was obviously delayed at 30 min after the injection. The results indicated the kidney was a major organ for puerarin distribution after CBN injection. But in model rats, the concentration of pueratinin kidney decreased, while increased in liver.
出处
《中国实验方剂学杂志》
CAS
2002年第3期41-43,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技部 95攻关项目 :No96 - 90 1 - 0 5 - 1 0 5
清华大学基础研究基金No.JC2 0 0 0 0 61
