摘要
目的 :探讨一氧化氮 (NO)、肿瘤坏死因子 (TNF -α)及内皮素 (ET)与脑卒中的相关关系及其临床意义。方法 :采用特异性放射免疫法和硝酸还原酶法测定 10 4例脑卒中 (急性脑梗死、急性脑出血各 5 2例 )患者及 5 0例健康人的外因血TNF -α、ET、NO的含量。结果 :急性脑卒中患者血清NO含量明显低于对照组 ,而TNF -α、ET含量则显著高于对照组 ,并随病情的稳定与好转发生变化。结论 :NO、TNF -α、ET可能参与脑卒中的疾病发展、演变过程 ,可作为判断脑卒中病情轻重和估计预后的一种参考指标。
Objective : The Clinical Significance and be relevant to nitric oxide(NO). Tumor necrosis factor-alpha(TNF-α) and Dndothelin (ET) With Stroke. Method : Using the nitrate reductase method and redioinmmunoassay,the blood NO,TNF-α and ET of 104 patients of stroke (acute Iscllemic and acute hemomhangic each 52 patients) and 50 normal People were measured. Results: acute stroke is ischemic or hemorrhagic,the blood NO of the patients were Signifi cantty decreased than which in the controls, And the TNF-α . ET of the patients wers higher than which in the controls,vary of follow state were stahilize and improve. Conclusion: NO.TNF-α and ET may be involved in the development of stroke,can serve and clinical markers of judging disease severity and prognosis.
出处
《河北医学》
CAS
2002年第3期224-226,共3页
Hebei Medicine
