摘要
以 5 ,10 ,15 ,2 0 四 (对羟基苯基 )卟啉 (2 )为原料 ,合成并表征了一系列水溶性和非水溶性的金属卟啉 .使用LKB 2 2 77热活性监测器测定了大肠杆菌在金属卟啉 4a～ 4f和 7a～ 7f作用下的生热曲线 ,得到了不同金属卟啉在不同浓度下大肠杆菌生长代谢的生热速率常数k ,最大发热功率pmax和最大发热功率的出现时间t.结果发现 ,含有吡啶溴化盐的水溶性金属卟啉 7a～ 7f对大肠杆菌生长代谢的抑制活性要明显大于含有酯基的金属卟啉 4a～ 4f.
Based on 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin (2), a series of water insoluble and water-soluble metalloporphyrins has been synthesized. An LKB-2277 thermal activity monitor was used to monitor the cell metabolic activity in vitro to produce thermogenesis curves. The growth rate constants k, maximum heat production rates p(max) and peak time of growth thermogenic curves t of E. coli in different metalloporphyrins at different concentrations were deduced from these thermogenesis curves. Metalloporphyrins 4a similar to 4f and 7a similar to 7f show inhibiting action on the growth metabolism of E. coli with water-soluble metalloporphyrins 7a similar to 7f being the better ones.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2002年第5期917-925,共9页
Acta Chimica Sinica
基金
国家自然科学基金 (No .2 9972 0 35 )
武汉大学自强科学基金 2 0 0 0年资助项目
