摘要
目的 研究血管内皮生长因子 (VEGF)在胃癌、结肠癌中的表达及意义。 方法 应用免疫组织化学技术 ,检测 35例胃癌、2 1例结肠癌中VEGF的表达。 结果 35例胃癌、2 1例结肠癌组织中 ,VEGF表达总阳性率 6 7.86 % (38/5 6 ) ,有淋巴结转移者VEGF表达阳性占 75 .6 1% (31/4 1) ,无淋巴结转移VEGF表达阳性占 4 6 .6 7% (7/15 ) (χ2 =4 .35 ,P <0 .0 5 )。癌组织浸润至浆膜层及浆膜外者VEGF表达阳性占 77.5 0 % (31/4 0 ) ,浸润至肌层及粘膜层者VEGF表达阳性占 4 3.75 % (7/16 ) (χ2 =6 .71,P <0 .0 1)。 结论 VEGF促进胃癌、结肠癌的生长、侵袭与转移 。
Objective To study the expressions of VEGF in gastric and colonic cncer. Methods The VEGF was detected by immunohistochemical method in 56 surgical samples of gastric or colonic cancer. Results Total positive rate of VEGF expression in gastric and colonic cancer was in 67.86%(38/56). In patients with lymphnode metastasis,the positive rate of VEGF expression was 75.61% (31/41), while in patients without lymphnode metastasis,the positive rate was 46.67%(7/15),χ 2=4.35, P<0.05. In patients with cancer tissue invaded into or beyond the serosa, the positive rate was 77.50%(31/40).In patients with cancer tissue invaded only into muscle or mucosa,the positive rate was 43.75%(7/16), χ 2=6.71,P<0.01. Conclusion VEGF can promote the growth, invasion and metastasis of gastric and colonic cancer, it play an important role in the tumor prognosis.
出处
《现代实用医学》
2002年第4期180-181,共2页
Modern Practical Medicine
关键词
胃癌
结肠癌
血管内皮生长因子
病理学
免疫组织化学
Gastric tumor/pathology Colonic tumor/pathology Lymphaokine+epithelial growth factor Immunohistochemistry/method
