摘要
目的 采用食饵性兔动脉粥样硬化 (AS)为模型 ,探讨辛伐他汀对食饵性兔AS形成过程中血浆内皮素 (ET)、血清一氧化氮 (NO)的作用。方法 雄性新西兰兔 4 2只 (1 92 4± 0 175kg) ,随机分为正常对照组、AS模型组和辛伐他汀组。在实验前、造模第 8、12周末分别测定ET、NO及主动脉AS面积。结果 在AS形成的中期和晚期 ,辛伐他汀组主动脉AS面积及ET均显著低于AS模型组 (P <0 0 1) ;实验第 12周末辛伐他汀组及AS模型组NO均低于正常对照组 (P <0 0 5～ 0 0 1) ,且辛伐他汀组NO与AS模型组无显著差异 (P >0 0 5 )。结论 辛伐他汀能阻抑AS时ET的升高 。
Objective The purpose of this study was to investigate the effects of simvastatin on endothelin and nitric oxide with atherosclerosis rabbits induced by high cholesterol dieatry.Methods 42 rabbits were randomized into three groups. The one group did not receive treatments and served as normal control group, the second group were fed regular chow with cholesterol and served as a atherosclerosis group. The groups(simvastatin group) were fed the cholesterol enriched diet in conjunction with simvastatin (Zocor)in a daily oral dose. The extent of aortic atherosclerosis was measured by planimetry of the sudanophilic area.Nitric oxide(NO) and endothelins(ET) were determined by chromatometry and radioimmunoassay separately for assessment the function of endothelium.Results At the end of 8 and 12 weeks treatment, the levels of aortic atherosclerosis areas and ET in simvastatin group were less significantly than that in atherosclerosis group( P <0 01);Only at the end of 12 weeks treatment, the levels of NO in both simvastatin and atherosclerosis groups reduced significantly than that in normal control group, but there ware not different between atherosclerosis group and simvastatin group.Conclusion Simvastatin inhibited ET in atherosclerosis rabbits induced by high cholesterol dietary, which may be related to its anti atherosclerosis role.
出处
《重庆医学》
CAS
CSCD
2002年第4期259-261,共3页
Chongqing medicine
基金
国家自然科学基金资助项目 (NO 3960 0 0 4 1 )
