摘要
目的观察正常血脂水平急性冠状动脉综合征(ACS)患者早期白介素-6(IL-6)和高敏C反应蛋白(hs-CRP)水平变化及辛伐他汀早期治疗对其干预效果。方法将血脂水平正常的 ACS患者随机分为辛代他汀治疗组(20 mg/d×4周)和常规治疗对照组(各40例),另选择同期健康对照者40例作为健康对照组。分析比较组间及两组ACS患者治疗前后血清IL-6和hs-CRP水平变化。结果两组ACS患者血脂水平与健康对照组比较无显著性差别,但其IL-6和hs—CRP水平均显著高于健康对照组(P<0．01);辛伐他汀治疗2周时血脂水平无显著变化,但IL-6和hs—CPP水平显著降低(P<0．01),治疗4周时血清总胆固醇和低密度脂蛋白胆固醇及IL-6、hs-CRP水平均显著降低 (P<0．05,P<0．01)且显著低于常规对照组(P<0．05)。结论血脂水平正常的ACS患者同样存在明显的炎症反应,辛伐他汀具有独立于调脂的抗炎作用,其快速抗炎作用在ACS患者早期治疗中可能具有重要意义。
Objective To study the effeet of Simvastatin on serum interleukin 6 （IL-6） and highsensitivity C-reactive protein （hs-CRP）in patients of acute coronary syndrome with normal lipid level in early stage. Methods 80 patients of ACS with normal lipid level were divided into routine controlled group （n = 40） with conventional drugs and simvastatin treated group （n = 40） with added simvastatin 20 mg per day within 48 hours from onset. 40 healthy subjects were selected as normal controlled group. The level of IL-6 and hs-CRP were measured before and after 2 and 4 weeks treatment. Results The lipid level in two ACS groups were similar to normal controlled group, but its level of IL-6 and hs-CRP were all increased significantly （P 〈 0.01 ）. After two weeks treatment with simvastatin, the lipid level was not significantly changed, however, the level of IL-6 and hs-CRP were decreased significantly （P 〈 0.01）. After four weeks treatment with simvastatin, the total cholesterol, low density lipoprotein cholesterol, IL-6 and hs-CRP were all lowered significantly （P 〈 0.05）. Conclusion The inflammatory may esist in patients of ACS with normal lipid level. Simvastatm possess anti-inflammatory effect which independent of its lipid lowering action, and the rapid anti-inflammatory effect of simvastatiw might play an important role in the early treatment of ACS with normal lipid level.
出处
《中国分子心脏病学杂志》
CAS
2006年第2期78-80,共3页
Molecular Cardiology of China
