摘要
利用实验性高脂血症动物模型,观察海洋贝类提取物(EMS)预防用药时的调血脂作用。将EMS与高脂饲料同时喂饲鹌鹑,于用药2,4,6,8,11周末时测定血清脂质含量。结果显示,EMS(生药)5、10、20g·kg-1均可显著降低鹌鹑血清甘油三酯水平(P<0.05,P<0.01),对血清低密度脂蛋白和载脂蛋白B的升高也有程度不等的抑制作用(P<0.05)。EMS20g·kg-1可使血清胆固醇明显降低(P<0.05),并提高血清高密度脂蛋白的水平(P<0.05)。提示EMS对实验性高血脂症有预防作用。
AIM To study of preventive action of extract from maritime shellfish (EMS). METHODS The hyperlipoidemia model in quails was induced exogenously by hyperlipoidal feed of 1% cholesterol, 14% lard, 6% peanut oil, and oral EMS at the same time. The lipoid in serum was determined for 2,4,6,8,11 weeks after administration. RESULTS EMS 5,10, 20 g. kg-1 sign efficiently reduced serum TC(P<0. 05,P<0. 01) ,and inhibited promotion of serum LDL-C and apo B in varying degrees (P>0. 05). EMS 20g昸g-1 evidently lowered the serum TC and rised the HDL-C concentration (P<0. 05). CONCLUSION EMS have the preventive action of regulating lipoidemia on experimental hyperlipoidemia.
出处
《中国海洋药物》
CAS
CSCD
2002年第2期31-33,共3页
Chinese Journal of Marine Drugs
基金
山东省科委基金资助(项目编号:981164805)
关键词
海洋贝类
高血脂症
预防
Meat of Maritime shellfish
Hyperlipoidemia
Quail
Preventive action
