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小分子药物在半结晶乙烯-醋酸乙烯酯共聚物(EVA)中的扩散机理:自由体积理论 被引量:5

DIFFUSION MECHANISM OF DRUG THROUGH SEMI-CRYSTALLINE ETHYLENE-VINYL ACETATE COPOLYMER:FREE VOLUME THEORY
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摘要 Free volume theory was applied to the diffusion mechanism of drug through semi crystalline ethylene vinyl acetate (EVA) copolymer. According to free volume theory, drug diffused through semi crystalline EVA via vinyl acetate segments of the copolymer, and the dependence of D (D: diffusion coefficient of drug through EVA) on a (a :vinyl acetate content of copolymer; a <0.5) could be described as ln (D)=A1-A2/a(A1, A 2:constant). This was demonstrated by experimental data from several references. Free volume theory was applied to the diffusion mechanism of drug through semi-crystalline ethylene-vinyl acetate (EVA) copolymer. According to free volume theory, drug diffused through semi-crystalline EVA via vinyl acetate segments of the copolymer, and the dependence of D ( D:diffusion coefficient of drug through EVA) on a ( a: vinyl acetate content of copolymer; a < 0.5) could be described as ln (D) = A1 = A2/a (A1, A2: constant). This was demonstrated by experimental data from several references.
出处 《高分子学报》 SCIE CAS CSCD 北大核心 2002年第2期242-244,共3页 Acta Polymerica Sinica
基金 国家自然科学基金资助项目 (基金号 5 9673 0 17)
关键词 乙烯-醋酸乙烯酯共聚物 扩散 自由体积理论 小分子药物 扩散控制释药体系 semi-crystalline ethylene-vinyl acetate copolymer diffusion coefficient free volume theory drug
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