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白介素2受体及其与肿瘤免疫逃逸 被引量:5

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摘要 白介素 2 (IL 2 ) /白介素 2受体 (IL 2R )在细胞因子网络调节中起关键作用。至少有三种IL 2R亚基 :α、β和γ链 ,β链和γ链是形成功能性IL 2R的必需亚基。IL 2与IL 2R结合激活多种信号转导途径 ,其中Jak STAT最为重要。IL 2R及其下游信号分子缺陷可能是肿瘤免疫逃逸的重要原因 ,纠正这种缺陷可用于肿瘤治疗的尝试。
出处 《上海免疫学杂志》 CSCD 北大核心 2002年第2期132-134,共3页 Shanghai Journal of Immunology
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  • 1Xuetao Cao,Guoyou Chen,Long He,Weiping Zhang,Yizhi Yu,TianXing Ye.Chemoattractive effect on the effector cells of the supernatants from melanoma cells transfected with the interleukin-2 (IL-2), IL-4 or IL-6 gene[J]. Journal of Cancer Research and Clinical Oncology . 1998 (2) 被引量:1
  • 2Paul B. Chapman,Jonathan E. Kolitz,Thomas B. Hakes,Janice L. Gabrilove,Karl Welte,V. J. Merluzzi,Adelheid Engert,Edward C. Bradley,Michael Konrad,Roland Mertelsmann.A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma[J]. Investigational New Drugs . 1988 (3) 被引量:1
  • 3Chapman PB,Kolitz JE,Hakes TB,et al.A phase Ⅰ trial of intraperitoneal recombinant interleukin-2 in patients with ovarian carcinoma. Investigational New Drugs . 1988 被引量:1
  • 4Stewart JA,Belinson JL,Moore AL,et al.Phase Ⅰ trial of intraperitoneal recombinant interleukin-2/lymphokine-activated killer cells in patients with ovarian cancer. Cancer Research . 1990 被引量:1
  • 5Aoki Y,Takakuwa K,Kodama S,et al.Use of adotive transfer of tumor infiltrating lymphocytes alone or in combination with cisplatin-containing chemotherapy in patients with epithelial ovarian cancer. Cancer Research . 1991 被引量:1
  • 6Howard OMZ,Kirken RA,Garcia GG,et al.Structural domains of interleukin-2 receptor βcritical for signal transduction: kinase association and nuclear complex-formation. European Journal of Immunology . 1996 被引量:1
  • 7Erard F,Corthesy P,Nabholz M,et al.Interleukin-2 is both necessary and sufficient for the growth and differentiation of lectinstimulated cytolytic T lymphocytes precusors. J Immunol . 1985 被引量:1
  • 8Grimm EA,Mazumder A,Zhang HZ,et al.Lymphokine-activated killer cell phenomenon lysis of natural killer-resistant fresh solid tumor cells by interleukin-2 activated autologous human peripheral blood lymphocytes. The Journal of Experimental Medicine . 1982 被引量:1
  • 9Mulders P,Tso CL,Pang S,et al.Adenovirus-mediated interleukin-2 production by tumors induces growth of cytotoxic tumor infiltrating lymphocytes against human renal cell carcinoma. J Immunol . 1998 被引量:1
  • 10Cao X,Chen G,He L,et al.Chemoattractive effect on the effector cells of the supernatants from melanoma cells transfected with the interleukin 2 (IL-2), IL-4, or IL-6 gene. Journal of Cancer Research and Clinical Oncology . 1998 被引量:1

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