摘要
目的 探讨视网膜母细胞瘤 (Retinoblastoma ,RB)发病年龄与肿瘤细胞分化程度及其与预后的关系。方法 光镜下观察2 91名RB患儿的 2 97只眼球的病理切片 ,并追踪观察患儿的预后。将肿瘤细胞的分化程度分为四级 ,即肿瘤细胞完全未分化(D0 ) ;分化的肿瘤细胞所占的范围 <1/ 3肿瘤面积 (D1) ;1/ 3～ 2 / 3肿瘤面积 (D2 ) ;>2 / 3肿瘤面积 (D3)。结果 年龄 <6个月 ,肿瘤细胞分化最好 (D3) ,年龄在 6～ 12个月者 ,肿瘤细胞分化较好 (D2 ) ,年龄 >36个月 ,肿瘤细胞分化不良 (D1) ,年龄在 2 4～30个月者 ,肿瘤细胞未分化 (D0 )。 4例 15～ 2 4个月的患儿死于肿瘤细胞转移 ,肿瘤细胞分化程度在D0 -D1。结论 2岁以前患儿肿瘤细胞的分化程度较高。若在此年龄段患儿的肿瘤细胞分化不良 ,又同时伴有脉络膜浸润和 /或视神经浸润 ,应视为预后不好的指征。
Objective To study the relation between the age of onset of disease and the degree of differentiation of the tumor cells with the prognosis of the disease. Methods Patho-histological sections of 297 eyes in 291 cases of retinoblastoma were observed under light microscope and the patients were followed up for their survival. The degree of differentiaion of the tumor were divided into 4 ranks: the cells were com pletely differentiated (D0) differentiated cells <1/3 area of tumor (D1) differentiated cells 1/3～ 2/3 area of tumor (D2), >2/3 area (D3). Results Patients' age under 6 months had the best differentiated tumors (D3), age between 6～12 months had relatively good differentiated tumors (D2), age over 36 months had less differentiated tumors (D1) and age 24～36 months had undifferentiated tumors (D0). 4 children with age 15～24 months died of tumor metastasis, their tumor cells differentiation degree were D0～D1. Conclusion The retinobla cells of children under 2 years of age were relatively better differentiated than those of younger children. If the tumor cells in this age group of children were poorly differentiated and accompanied by choriodal and/or optic nerve infiltration, the prognosis is poor.
出处
《肿瘤》
CAS
CSCD
北大核心
2002年第2期124-126,共3页
Tumor
