摘要
①目的 探讨测定癌胚抗原 (CEA)、非小细胞肺癌标志物 (CYFRA2 1 1)和神经元特异性烯醇化酶(NSE)对良恶性胸腔积液的鉴别诊断价值。②方法 用放射免疫法分别测定胸腔积液病人血清和胸腔积液的CEA ,CYFRA2 1 1,NSE水平 ,并评价联检对其的诊断价值。③结果 恶性胸腔积液病人血清中CEA ,CYFRA2 1 1,NSE水平均显著高于良性胸腔积液组 (t =2 .789～ 3.2 2 1,P <0 .0 5 ) ,且其胸腔积液 /血清的比值 >1,CEA和CYFRA2 1 1联用时灵敏度为 85 .4 % ,再加NSE ,则灵敏度达 92 .7% .④结论 CEA ,CYFRA2 1 1,NSE中二项或三项联检有一定诊断意义 ,如结合胸腔积液 /血清比值 >1,则诊断意义更大。
Objective\ To evaluate the role of detection of carcinoembryonic antigen (CEA), cytokeratin subunit 19 ( CYFRA21 1 ) and specific enolase (NSE) in differential diagnosis of benign and malignant pleural effusion. \ Methods\ The levels of CEA, CYFRA 21 1 and NSE were detected both in serum and pleural fluid of patients with pleural effusion by means of immunoradiometric assay. The diagnostic value of combined assay of these three tumor markers was evaluated. \ Results\ The levels of CEA, CYFRA 21 1 and NSE in serum and pleural fluid taken from patients with malignant pleural effusion were all significantly higher compared with those from patients with benign pleural effusion( t=2.789-3.221, P <0.05), the ratio of pleural fluid / serum was more than one. The sensitivity rate was 85.4% when the combination of CEA and CYFRA 21 1 was applied, the rate reached 92.7% when the three markers were combined. Conclusion \ The combination of these three or two markers was of clinical significance in the diagnosis of malignant effusion, if the ratio of pleural fluid / serum was more than one, it would be more significant.
出处
《齐鲁医学杂志》
2002年第1期35-36,共2页
Medical Journal of Qilu
关键词
胸腔积液
肿瘤标记
生物学
诊断
pleural fluid
tumor markers, biological
diagnosis
