摘要
目的:探讨不同病理类型的狼疮肾炎患者的肾脏损伤与血清中肿瘤坏死因子和可溶性肿瘤坏死因子受体的相关性。方法:B超引导下对23例狼疮肾炎行肾组织活检并做病理分型;同时应用ELISA方法测定患者及30例正常对照组血清中肿瘤坏死因子和可溶性肿瘤坏死因子受体的水平。结果:本组患者的肾脏活检病理分型为Ⅱ、Ⅲ、Ⅳ和Ⅴ型;患者血清中肿瘤坏死因子和可溶性肿瘤坏死因子受体的水平明显高于正常对照组（P<0.01）,且随病理损伤程度的加重其表达水平亦增高,4组间有显著差别（P<0.05）。结论:狼疮肾炎患者的肿瘤坏死因子和可溶性肿瘤坏死因子受体参与了疾病的免疫损伤机制,它们可作为一种间接判断肾脏损伤程度的依据。
: To investigate the correlation between pathological classification and the levels of TNF and sTNF in sera from patients with lupus nephritis (LN). Methods: Kidney biopsy and pathological analysis were carried out for 23 patients. Sera TNF and sTNF- R were tested for in these patients and 30 normal controls ELISA assay. Results: Pathological analysis showed that the patients were typeⅡ、type Ⅲ、type Ⅳand typeⅤ, Serum levels of TNF and sTNF in LN were significantly higher than that in normal controls(P <0. 01), and they increased as kidney injury aggravated. Besides, there was significant difference among patients with different pathological patterns of LN(P<0.05). Conclusion: TNF and sTNF -R may be involved in the mechanism of the immune injury of the disease and may also be served as indirect signs for evaluating the severity of kidney injury.
出处
《中国临床医学》
2002年第1期7-8,共2页
Chinese Journal of Clinical Medicine
基金
福建省教委科学基金资助项目(K98032)
