摘要
当细胞遭受各种压力刺激后,内质网会积累大量未折叠蛋白,产生内质网应激,对细胞产生损害。为了削弱这种损害,细胞会通过启动未折叠蛋白应答途径,促进下游基因表达来帮助细胞生存。近年来报道发现膜结合转录因子在其中发挥重要作用。膜结合转录因子是一种特殊的转录因子,具有核定位信号和跨膜域,在内质网应激中被活化进入到细胞核启动未折叠蛋白反应帮助细胞度过不良环境,因此了解这类转录因子的活化机制至关重要。本综述就膜结合转录的3种活化机制:泛素化蛋白酶体介导的RUP途径、胞内蛋白酶介导的RIP途径以及mRNA水平的非常规剪切途径进行概述,并对未来的研究提出展望。
When cells are exposed to various stresses, large amounts of unfolded proteins will be accumulated in endoplasmic reticulum(ER), which results in ER stress and does harm to cells. Cells will trigger a well-conserved pathway called the unfolded protein response(UPR) to mitigate the damage and promote the expression of downstream genes to help cell survival. In recent years, it has been reported that membrane-bound transcription factors play an important role in ER stress. The membrane-bound transcription factor is a special transcription factor,which has nuclear localization signals and trans-membrane domains. The membrane-bound transcription factors are activated into the nucleus to initiate unfolded protein responses and help cell to survive under endoplasmic reticulum stress. Thus, it is important to understand the activation mechanism of the membrane-associated transcription factors. This review summarized the three activation mechanisms of membrane-bound transcription factor: the ubiquitin-proteasome-mediated RUP pathway, the intracellular protease-mediated RIP pathway, and the mRNA level of unconventional cleavage pathway, and put forward the forecast to future research.
作者
杨正婷
熊孟连
简燕
李琨
乙引
Yang Zhengting;Xiong Menglian;Jian Yan;Li Kun;Yi Yin(Key Laboratory of Plant Physiology and Development Regulation of Guizhou Province,School of Life Sciences,Guizhou Normal University,Huaxi, 550025)
出处
《分子植物育种》
CAS
CSCD
北大核心
2018年第24期8028-8033,共6页
Molecular Plant Breeding
基金
国家自然科学基金一青年基金(31600214)
贵州省科学技术基金计划重点项目(黔科合基础[2016]1412)
贵州省重点实验室建设项目(黔科合计Z字[2011]4005)共同资助.
关键词
内质网应激
膜结合转录因子
活化机制
Endoplasmic reticulum stress
Membrane-associated transcription factor
Activation mechanism
