摘要
目的分析儿童抗磷脂综合征(APS)合并肺栓塞患儿的临床特征。方法回顾性分析2007年1月至2017年1月本科收治18例儿童APS合并肺栓塞患儿的临床资料,对其临床及免疫学指标变化进行总结。结果本组APS合并肺栓塞患儿原发性APS与继发性APS各9例,肺栓塞均属于非休克型,以肺栓塞为首发临床表现共9例患儿;有15例患儿同时存在深静脉血栓,以下肢的深静脉为主。原发性APS中2例发生肺栓塞/下肢深静脉血栓复发。原发性APS与继发性APS比较,男患儿比例较高(7/9 vs 1/9,χ2=28. 033)、发病年龄提前[(12. 3±1. 1)岁vs (16. 5±1. 2)岁,t=5. 361],差异有统计学意义(P <0. 05)。结论儿童APS合并肺栓塞患儿首发症状可能为肺栓塞且属于非休克型,多伴发下肢的深静脉血栓形成。原发性APS抗核抗体阳性率较高,与继发性APS比较临床相关指标及免疫学指标差异不大。
Objective To identify the clinical characteristics of pediatric antiphospholipid syndrome (APS)patients with pulmonary embolism.Methods The clinical data of 18 children with APS combined with pulmonary embolism treated in our department from January 2007 to January 2017 were retrospectively analyzed.The clinical and immunological indexes of the APS patients with pulmonary embolism were summarized.Results 18 patients(among whom 9 cases were primary APS and the other 9 cases were secondary APS)had pulmonary embolism and all of them were non-shock type,which was the first presenting manifestation in 9 cases of them.15 patients suffered from deep vein thrombosis at the same time,mainly in lower extremities.2 patients had thrombotic recurrence in primary APS.Primary APS was more often seen in males (7/9 vs 1/9,χ^2 =28.033 )and much yonger [(12.3 ±1.1 )years vs (16.5±1.2)years,t = 5.361 ]than those with secondary APS,with statistically significant differences (P <0.05 ).Conclusions Pulmonary embolism can be the first symptom in prediatric APS patients and all of them are non-shock type. A majority of them suffer from deep vein thrombosis in the lower extremities.Positive anti-nuclear antibodies can be seen in primary APS patients,but there is no significant difference between primary APS and secondary APS about the clinical and immunological indexes.
作者
周群玲
梁传乐
黄莹萱
Zhou Qunling;Liang Chuanle;Huang Yingxuan(Department of Paediatrics,The First People's Hospital of Qinzhou City,Qinzhou 546300 China)
出处
《中国医师杂志》
CAS
2019年第1期94-97,共4页
Journal of Chinese Physician
关键词
抗磷脂综合征
肺栓塞
儿童
Antiphospholipid syndrome
Pulmonary embolism
Child