摘要
现有的单腔室呼吸力学集中参数模型采用一个线性或非线性气阻元件描述整个气管-支气管树对气流的阻碍作用,忽略了各级气道具备不同的力学特性这一事实。因此,基于气管-支气管树的解剖结构及各级气道的力学特性,本文将人体呼吸道分为上气道、陷闭气道、小气道三部分,建立了多腔室、非线性气道分级的呼吸力学集中参数模型。该模型以呼吸肌为自主呼吸动力,模拟了健康成人的自主潮气呼吸过程。结果显示,本文所构建的自主呼吸模型的计算结果与人体呼吸生理过程较为吻合,并与已有文献的研究结果相似,提示本模型可用于呼吸系统病理生理研究。
One-compartment lumped-parameter models of respiratory mechanics,representing the airflow resistance of the tracheobronchial tree with a linear or nonlinear resistor,are not able to describe the mechanical property of airways in different generations.Therefore,based on the anatomic structure of tracheobronchial tree and the mechanical property of airways in each generation,this study classified the human airways into three segments:the upper airway segment,the collapsible airway segment,and the small airway segment.Finally,a nonlinear,multi-compartment lumped-parameter model of respiratory mechanics with three airway segments was established.With the respiratory muscle effort as driving pressure,the model was used to simulate the tidal breathing of healthy adults.The results were consistent with the physiological data and the previously published results,suggesting that this model could be used for pathophysiological research of respiratory system.
作者
刘天亚
乔惠婷
李德玉
樊瑜波
LIU Tianya;QIAO Huiting;LI Deyu;FAN Yubo(Beijing Advanced Innovation Centre for Biomedical Engineering,Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,P.R.China;Beijing Key Laboratory of Rehabilitation Engineering for Elderly,National Research Center for Rehabilitation Technical Aids,Beijing 100176,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2019年第1期101-106,115,共7页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(11421202)
国家重点研发计划资助项目(2016YFC1304305)
科技支撑计划项目(2015BAI02B00)
关键词
呼吸系统
呼吸力学
自主呼吸
气道分级模型
respiratory system
respiratory mechanics
spontaneous breathing
airway-segmented model
