摘要
通过测定不同配比的十二烷基三甲基溴化铵(DTAB)和Tween 80的临界胶束浓度(CMC)、摩尔增溶比(MSR)和姜黄素(Cur)在碱性水溶液(pH 13)及表面活性剂复配碱性溶液中的降解速率(k)来考察表面活性剂的复配对姜黄素的增溶及保护作用。结果显示,单独使用Tween 80时,增溶能力强但稳定性差;单独使用DTAB时,稳定性好但是增溶能力差;二者以不同的比例复配后稳定性均增强,当DTAB摩尔分数为0.4时,稳定性最好,虽然此时增溶能力不是最好,但是相比于单独使用DTAB, MSR增加了1.7倍。表面活性剂复配在增加溶解度的同时还能增加稳定性,此外,表面活性剂复配具有用量少、毒性小等优点,值得推广。
The solubilization and protection of curcumin(Cur) by mixed surfactants were studied through thedetermination about the critical micellar concentration(CMC) of the mixed surfactants of Tween 80 and dodecyltrimethyl ammonium bromide(DTAB), molar solubilization ratio(MSR), degradation rate(k) of Cur in pH 13 solution and mixed surfactant solutions prepared at pH 13. The results showed that when Tween 80 was used alone,it exhibited high solubilization ability but poor stability. DTAB was used alone, it showed strong stability but poorsolubilization ability. When DTAB was mixed with Tween 80 at different mole fractions, the stability of Cur wasenhanced, and the best stability was observed when the mole fraction of DTAB was 0.4, although the solubilizationability was not the best at this mole fraction, but MSR was increased by 1.7 times compared to DTAB used alone.Mixed surfactant not only increased the solubility but also improved the stability of Cur. In addition, mixed surfac-tant has the advantages of less dosage and low toxicity, which is worth popularizing in application.
作者
刘调调
杨白雪
郭瑛玉
陈娜
李三鸣
LIU Tiao-tiao;YANG Bai-xue;GUO Ying-yu;CHEN Na;LI San-ming(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《药学学报》
CAS
CSCD
北大核心
2019年第1期8-13,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81473161)
国家科技重大专项资助项目(2017ZX09101001-006-012)
关键词
表面活性剂复配
临界胶束浓度
姜黄素
增溶
保护
mixed surfactant
critical micellar concentration
curcumin
solubilization
protection
