摘要
目的分析开颅术后丙戊酸钠相关性高血氨脑病(VHE)的临床表现和预后效果。方法回顾性收集2015年12月至2016年12月该院收治的6例开颅术后VHE患者资料,并进行分析。结果 6例患者中4例首发临床表现为烦躁,5例丙戊酸钠血药浓度与血氨水平均高于正常范围,但两者之间无相关性,影像学检查均无明显变化。最后5例患者痊愈,1例死亡。痊愈患者中1例肝功能正常,4例出现迟发性肝功能损伤。结论一旦确诊VHE,及时对症处理十分关键。
Objective To analyse the clinical characteristics and recovery of patients with valproate-induced hyperammonemic encephalopathy(VHE)after craniotomy.Methods Data of six patients with VHE after craniotomy from December 2015 to December 2016 were collected and analysed.Results Four patients showed irritable as the first clinical symptom.Five patients′plasma drug concentrations of valproate and blood ammonia level were high,but there was no correlation between them.And their imaging examinations presented no difference.Finally,1 patient died and 5 patients recovered.Among those who recovered,4 patients had tardive liver damage.Conclusion Once the diagnosis is made as VHE,prompt symptomatic management is critical.
作者
邓瑛瑛
朱敏芳
陈飞亚
雷清梅
包赟
邱炳辉
DENG Yingying;ZHU Min fang;CHEN Feiya;LEI Qingmei;BAO Yun;QIU Binghui(Department of Neurosurgery,Southern Medical University Nan fang Hospital,Guangzhou,Guangdong 510515,China)
出处
《重庆医学》
CAS
2019年第1期61-63,共3页
Chongqing medicine
基金
广东省医学科研基金项目(C2016062)
南方医科大学南方医院院长基金项目(2017H001)
关键词
丙戊酸
高血氨脑病
颅骨切开术
血浆氨浓度
valproic acid
valproate-induced hyperammonemic encephalopathy
craniotomy
ammonia concentration
