摘要
目的:探究N末端前脑利钠肽(NT-proBNP)在儿童先天性心脏病的变化及临床意义。方法:选取我院2011年至2016年间,患有由左向右分流型先天性心脏病(LRS)儿童受试者80例(男性35例,女性45例)参与研究(观察组)。选取80例健康儿童作为对照组。测定两组受试者的NT-proBNP。并用B超测定以下参数:收缩功能(EF和左心室短轴缩短率),肺循环与体循环血流量之比(Qp/Qs),肺动脉血流和肺动脉压,左心室舒张功能(E波,A波,E/A比值,减速时间),分析NT-proBNP与上述指标的相关性。结果:①观察组NT-proBNP水平显著高于对照组,其差异有统计学意义(P<0.05)。②在观察组中,心功能Ⅲ-Ⅳ级的患者NT-proBNP的水平明显高于心功能Ⅰ级和心功能Ⅱ级的患者,其差异有统计学意义(P<0.05)。③NT-proBNP升高组, EF低于NT-proBNP正常组,肺动脉血流,肺动脉压,Qp/Qs高于NT-proBNP正常组,其差异有统计学意义(P<0.05)。④经Pearson线性相关分析显示,NT-proBNP与射血分数呈负相关,与肺动脉血流、肺动脉压、Qp/Qs呈正相关。结论:NT-proBNP对于LRS的病情判断具有一定的参考价值。
Objective: To explore the level of NT-proBNP in patients with congenital heart disease, and to provide guidelines for clinical practice. Methods: 80 cases with left and right shunt congenital heart disease(LRS,35 males and 45 females) were enrolled in our hospital from 2011 to 2016. 80 healthy children were selected as the control group. NT-proBNP was measured for both groups of subjects.(Qp/Qs), pulmonary arterial blood flow and pulmonary artery pressure, left ventricular diastolic function(E wave, left ventricular echocardiography) and left ventricular diastolic function(E-wave) were measured by B-mode ultrasonography: systolic function(ejection fraction and left ventricular short axis shortening) A wave, E/A ratio, deceleration time). Results: ①The level of NT-proBNP in the experimental group was significantly higher than that in the control group, the difference was statistically significant(P<0.05). ②In the experimental group, the level of NT-proBNP in patients with NYHA Ⅲ-Ⅳ was significantly higher than that in patients with NYHA Ⅰ and cardiac function, the difference was statistically significant(P<0.05). ③NT-proBNP increased group, the EF%) was lower than that of NT-proBNP group, the pulmonary artery blood flow, pulmonary artery pressure and Qp/Qs were higher than NT-proBNP group, the difference was statistically significant(P<0.05). ④Pearson linear correlation analysis showed that NT-proBNP was negatively correlated with ejection fraction and positively correlated with pulmonary artery blood flow, pulmonary artery pressure and Qp/Qs. Conclusions: NT-proBNP has definite guideline value for LRS.
作者
刘一炫
赵雅红
谢富兰
蒙荣森
LIU Yixu-an;ZHAO Yahong;XIE Fulan;MENG Rongsen(Department of Cardiology,C.uangdong Second Provincial Cen- tral Hospital,Guangzhou 510317,China)
出处
《心肺血管病杂志》
2018年第12期1070-1073,共4页
Journal of Cardiovascular and Pulmonary Diseases
基金
国家自然科学基金(71373058)
关键词
N末端前脑钠肽
先天性心脏病
心功能
N-terminal prohormone of brain natriuretic peptide
Congenital heart disease
Cardiac
