摘要
目的肥胖不仅与2型糖尿病、高血压、心血管疾病及其他代谢性疾病有关,还参与肿瘤的生长、侵袭和转移等过程,是多种肿瘤预后不良因素。本研究通过总结肥胖与肿瘤、运动与肿瘤的相关性,以探讨肥胖和运动对肿瘤发生发展的可能机制,以及运动干预与肿瘤预防和发病率之间的关系。方法应用PubMed、Web of Science和CNKI期刊全文数据库检索系统,以"肿瘤、肥胖、运动"为关键词,检索2008-05-01-2018-05-30肥胖和运动与肿瘤关系的相关文献。共检索到中文文献42篇,英文文献426篇。纳入标准:(1)肥胖与肿瘤的关系;(2)运动与肿瘤的关系;(3)肿瘤发生发展与肥胖和运动的关系。剔除标准:(1)综述类文献;(2)研究资料不完善。根据纳入标准,符合分析的文献共34篇。结果肥胖与肿瘤发生发展有关,其中体质量指数(body mass index,BMI)与癌症患病风险呈明显的量效关系;肥胖率增高可能使机体各种肥胖因子如肿瘤坏死因子(tumor necrosis factor,TNF-α)、白细胞介素6 (interleukin-6,IL-6)、瘦素和脂连素等水平改变,从而直接或间接导致癌症发生。逃避免疫监测和肿瘤相关炎症被认为是癌症的标志,这两种现象都与癌症的发生和进展密切相关。体育锻炼有可能成为癌症辅助治疗疗法,长时间适当运动可减少C反应蛋白(C-reactive protein,CRP)、TNF-α、IL-6和其他炎性因子水平;有规律的中等强度运动锻炼还能改善机体免疫功能。结论肥胖是肿瘤的高危因素,可通过肿瘤相关炎性反应促进肿瘤发生、侵袭和转移。通过加强运动可减少肥胖的发生,有望成为预防癌症发生的方式之一。
OBJECTIVE Obesity is not only related to type 2diabetes,hypertension,cardiovascular disease and other metabolic diseases,but also involved in the growth,invasion and metastasis of tumors and other processes,and is a variety of poor prognosis factors of tumors.This study summarized the relationship between obesity and tumor,exercise and tumor,and explored the possible mechanism of obesity and exercise on the occurrence and development of tumor,as well as the relationship between exercise intervention and tumor prevention and incidence.METHODS PubMed,Web of Science and CNKI were employed to search for relevant literature on relationship between obesity,exercise and cancer from 2008-05-01 to 2018-05-30 by using keywords such as tumor,obesity and movement.A total of 42 Chinese papers and 426 English papers were retrieved.Eligibility criteria:(1)the relationship between obesity and tumor;(2)the relationship between exercise and tumor;(3)the relationship between tumor development and obesity and exercise.Exclusion criteria:(1)literature review;(2)the research data incomplete.Totally 34 articles have been included.RESULTS Obesity is related to the occurrence and development of tumors.Body mass index(BMI)has a significant dose-effect relationship with cancer risk.Increased obesity may cause changes in the body’s fat factors such as tumor necrosis factor(tnf-alpha),interleukin-6(IL-6),leptin,and adiponectin,which may directly or indirectly lead to cancer.Evasive immune surveillance and tumor-related inflammation are considered markers of cancer,both of which are closely related to the occurrence and progression of cancer.Physical exercise may become an adjuvant therapy for cancer.Long-term and appropriate exercise can reduce the level of c-reactive protein(CRP),tnf-alpha,IL-6and other inflammatory factors.Regular moderate intensity exercise can also improve the immune function of the body.CONCLUSIONS Obesity is a high risk factor for tumors and can promote tumor formation,invasion and metastasis through tumor-related in
作者
戚光
冯立勇
梁洪
QI Guang;FENG Li-yong;LIANG Hong(Physical Education Teachers' Office,Shandong Medical College,Linyi 276000,P.R.China;Breast Center,Linyi People's Hospital,Linyi 276000,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2018年第22期1611-1614,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
肿瘤
肥胖
运动
综述文献
tumor
obesity
movement
review literature
