摘要
银屑病发病机制复杂,尚未完全阐明。自1979年环孢素被发现用于治疗银屑病后,对银屑病发病机制的认识也由一种增殖分化异常性疾病(即角质形成细胞模式)向免疫相关性疾病(T细胞模式)转变。随着研究深入,T细胞模式中Th1、Th17、Th22、Treg、γδT细胞的作用逐渐被揭示,针对部分细胞及其相关细胞因子已开发出相应药物。
The pathogenesis of psoriasis is complicated and has not been fully elucidated. Since cyclosporin has been used to treat psoriasis,the understanding of its pathogenesis is also transforming from an epidermal proliferative disease (keratinocyte paradigm) to an immune-related disease(T-cell paradigm). With the development of research,the function of Th1,Th17,Th22,Treg,and γδT cell in the T cell paradigm has been revealed,and new drugs have developed based on some of these cells and related cytokines. The paradigm shift and treatment progress of psoriasis in a perspective of translational medicine were summarized.
作者
滕艳
刘毅
TENG Yan;LIU Yi(Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical Colleges, Nanjing 210042,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2019年第1期1-5,共5页
The Chinese Journal of Dermatovenereology
关键词
转化医学
银屑病
发病模式
治疗进展
Translational medicine
Psoriasis
Paradigm shift
Treatment progress
