摘要
目的:评价康艾注射液联合同步放化疗治疗中晚期宫颈癌的临床疗效;方法:采用Cochrane系统综述方法,检索Pubmed、Web of Science、中国知网、维普科技期刊数据库、万方数据学术论文总库,检索时间建库至2018年1月。获取同步放化疗联合与不联合康艾注射液治疗中晚期宫颈癌的随机对照试验文献,以近期疗效、放化疗不良反应、生活质量为评价指标,采用Cochrane协作网Review Manager 5. 3软件进行meta分析;结果:纳入6项RCT,共计570例中晚期宫颈癌患者中,在同步放化疗的治疗基础上配合康艾注射液与单同步放化疗的比较。发现,加用康艾注射液对中晚期宫颈癌患者的近期疗效增效显著[OR=3. 13,95%CI(2. 13,4. 79),P<0. 00001];对放化疗消化道不良反应的减轻作用明显[OR=0. 38,95%CI(0. 24,0. 61),P <0. 0001];对放化疗白细胞下降有一定的减轻作用[OR=0. 51,95%CI (0. 29,0. 88),P=0. 02];对患者生活质量有所提高[OR=3. 91,95%CI(2. 39,6. 39),P <0. 00001];结论:与单用同步放化疗治疗方案相比,配合使用康艾注射液可以提高近期疗效,降低放化疗不良反应,尤其是改善胃肠道反应方面疗效显著,并且提高患者生活质量。由于纳入试验质量和病例数目的限制,该结论需要进一步的研究证实。
Objective:To systematically review the efficacy of Kangai injection and chemoradiotherapy in treatment of advanced cervical cancer.Methods:Using the method of Cochrane systematic review,PubMed,web of science,China knowledge database,VIP journals database,Wanfang Data papers database,retrieval time by 2018.Randomized controlled trials for comparison with and without Kang'ai injection treatment in advanced cervical read in cancer,curative effect and adverse reactions of radiotherapy and chemotherapy,quality of life as the evaluation index,using the Cochrane Collaboration Review Manager 5.3software for meta analysis.Results:6 RCT involving 590 cases of advanced cervical cancer patients were adopted.The results showed that Kang'ai injection can significantly improve the recent efficacy of patients with advanced cervical cancer [or=3.13,95%ci(2.13,4.79,P<0.00001]),reduce adverse effects significantly for gastrointestinal patients after chemotherapy [or =0.38,95%ci(0.24,0.61),P<0.0001],control the reducing of white blood cells which caused by chemotherapy [or =0.51,95%ci(0.29,0.88,P =0.02])and improve the quality of life of patients [or =3.91,95%ci(2.39,6.39),P<0.00001].Conclusions:Compared with the synchronous chemoradiotherapy alone,with the use of Kang'ai injection can improve the curative effect and reduce the adverse reactions of radiotherapy and chemotherapy,improve the quality of life of patients.Due to the number of trials,this conclusion needs to be confirmed by further studies.
作者
崔蒙
池志恒
虞舜
CUI Meng;CHI Zhiheng;YU Shun(Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu Province,210023,China)
出处
《贵阳中医学院学报》
2019年第1期84-89,共6页
Journal of Guiyang University of Chinese Medicine
基金
江苏省优势学科建设工程项目
项目编号:苏政办发[2014]37号
关键词
康艾注射液
放化疗
宫颈癌
META分析
Kang'ai injection
radiotherapy and chemotherapy
cervical cancer
meta-analysis'
