摘要
[目的]探讨幽门螺杆菌感染在糖耐量异常和糖尿病患者中的变化。[方法]对44例空腹糖受损/糖耐量减低、42例糖尿病和114例正常对照者的年龄、性别、幽门螺杆菌感染、体质量指数、总胆固醇、三酰甘油、空腹血糖、肌酐、尿素氮和患高血压情况进行对比观察。[结果]年龄、幽门螺杆菌感染、体质量指数、三酰甘油和肌酐在糖尿病组、空腹糖受损/糖耐量减低组和正常对照组之间比较差异有显著性(P<0.05,P<0.01)。多因素binary logistic regression分析发现血糖和体质量指数是幽门螺杆菌感染的相关因子(P<0.05,P<0.01)。[结论]糖尿病和空腹糖受损/糖耐量减低患者幽门螺杆菌感染升高,空腹血糖水平与幽门螺旋杆菌感染相关。
[Objective]To investigate the Helicobacter pylori(Hp)infection in impaired fasting glucose(IFG),impaired glucose tolerance(IGT)and diabetes.[Methods]We observed age,Hpinfection,body mass index,total plasma cholesterol,plasma triglyceride,fasting glucose,plasma creatinine concentration,blood urea nitrogen and hypertension incidence in 114 normal glucose tolerance(NGT),44 IFG/IGT and 42 diabetes mellitus patients who were consecutively referred by general practitioners for routine medical check-up or medical treatment.[Results]Age,Hpinfection,body mass index,plasma triglyceride and plasma creatinine concentration were significant difference between NGT,IFG/IGT and diabetes mellitus group(P<0.05,P<0.01).Hpinfection was taken as a dependent variable and age,sex,body mass index,total cholesterol,triglyceride,fasting glucose,plasma creatinine concentration,blood urea nitrogen and hypertension incidence were taken as independent variables,we found that fasting plasma glucose(β=0.93,P<0.01)and body mass index(β=0.784,P<0.05)were significantly associated with the risk for Hpinfection analyzed by binary logistic regression.[Conclusion]Patients with diabetes mellitus and IFG/IGT were more likely to have Hpinfection,and fasting glucose was associated with Hpinfection.
作者
王赞滔
杨文
WANG Zan-tao;YANG Wen(Department of Gastroenterology and Hepatology,PLA General Hospital, Beijing,China.Beijing 100853,China;Geriatric Gastroenterology and Hepatology Department,Navy General Hospital,100048 Beijing,China)
出处
《临床消化病杂志》
2018年第6期352-355,共4页
Chinese Journal of Clinical Gastroenterology
基金
全军保健专项基金(No:17BJZ03)
关键词
糖尿病
空腹糖受损
糖耐量减低
幽门螺杆菌感染
diabetes mellitus
impaired fasting glucose
impaired glucose tolerance
Helicobacter pylori infection
