摘要
狂犬病病毒(rabies virus,RABV)是传染性强、死亡率高、受到人们广泛关注的一种烈性病毒。狂犬病疫苗作为目前唯一能预防和控制狂犬病的制剂,其研发和生产日益成为热点。佐剂是能增强或改变抗原特异性免疫应答从而辅助疫苗发挥作用的物质。目前上市的狂犬病疫苗主要为铝佐剂疫苗及无佐剂疫苗,但上述两种疫苗均存在较大的局限性,在一定程度上影响了狂犬病疫苗的使用效果,因此本文在对RABV及其致病机理进行综述的基础上,对狂犬病疫苗佐剂进行探讨。
Rabies virus,characterized by strong infectivity and high death rate,is a virulent virus which is paid attention widely.Currently,rabies vaccine is the only for prevention and control of rabies,of which the development and production are increasingly becoming the hotpots.Adjuvant is a compound which may strengthen or change the antigen-specific immune response thus assist in giving full play to the vaccine.At present,the rabies vaccines available in the market are mainly aluminum adjuvant-containing and adjuvant-free vaccines,of which the limitation affects the effectiveness of vaccination to a certain extent.Therefore,rabies vaccine adjuvant is discussed in this paper based on the review of rabies virus and its pathogenesis.
作者
赵祥月
普梦笛
鲁卫东
ZHAO Xiang-yue;PU Meng-di;LU Wei-dong(Key Laboratory of Natural Pharmacology and Pharmacology,School of Pharmacy,Kunming Medical University,Kunming 650500,Yunnan Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2018年第12期1397-1401,共5页
Chinese Journal of Biologicals
关键词
狂犬病疫苗
佐剂
Rabies vaccine
Adjuvant
