摘要
目的对建立适用于中国患者的基于症状的慢性阻塞性肺疾病(COPD)筛查问卷进行初步探讨。方法720例入选患者被随机分为推导组(570例)和外部验证组(150例),均填写筛查问卷并进行肺通气功能检查。推导组资料经统计学分析确定问卷条目分值,验证组资料用以验证问卷的有效性。结果16个问卷条目中有8项条目进入最终问卷,分别是年龄、体质量指数(BMI)、吸烟总量(年包)、不感冒时咳嗽咳痰、天气变化时咳嗽、晨起咳痰、气促指数、过敏史。经多元回归分析得出问题条目评分值,ROC曲线分析结果表明以17.5分为截断点时,问卷的敏感性为80%,特异性为70%。结论初步研究形成的基于症状的COPD筛查问卷可用来筛查中国的COPD高危人群。
Objective Try to develop a symptom‐based questionnaire for identifying COPD in China .Methods 720 participants were randomly divided into "development subsample" (570 cases) and "external validation subsample" (150 cases) ,all fulfilled the questionnaires and the pulmonary function test .The "development subsample" was used to create the questionnaires ,while a "external validation subsample" was used to evaluate the performance characteristics of the questionnaires . Results There were 16 items for analysis ,which was reduced to 8 items had significant relationships with the study diagnosis of COPD ,including age ,BMI ,total smoking (annual packs) ,cough and phlegm without a cold , weather‐affected cough , morning phlegm ,wheeze frequency and history of any allergies .Scores for individual questions were based on the regression coefficients from logistic regression models .We created a cut‐off value of 17 .5 points by ROC analysis ,the sensitivity and specificity were 80% and 70% . Conclusions The questionnaires can help preliminary screen COPD patients in China .
作者
任涟萍
张悦
施萍
吴斌
郭雪君
Ren Lianping;Zhang Yue;Shi Ping;Wu Bing;Guo Xuejun(Department of Resp iratory Medicine ,Shanghai Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine ,Shanghai 200092,China)
出处
《国际呼吸杂志》
2018年第23期1766-1770,共5页
International Journal of Respiration
基金
上海市科委基金(17511108502)。
关键词
慢性阻塞性肺疾病
筛查问卷
研究
Chronic obstructive pulmonary disease
Screening questionnaires
Study
