摘要
乳腺癌是影响女性健康最主要的恶性肿瘤之一.表观遗传修饰及活性氧(ROS)过度积累引起的氧化应激在乳腺癌发生发展中起关键作用,表观遗传修饰与ROS的生成和清除相互影响.本文通过对目前有关表观遗传修饰和ROS参与乳腺癌的发生发展进行综述,为寻求乳腺癌发生发展的生物标志物及精准治疗提供思路.
Breast cancer is one of the most important malignant tumors affecting women’s health.Epigenetic modification and oxidative stress caused by excessive accumulation of reactive oxygen species(ROS)play a key role in the occurrence and development of breast cancer.In addition,epigenetic modification and the production and clearance of ROS interact with each other.In this paper,epigenetic modification and ROS involved in the occurrence and development of breast cancer are reviewed in order to provide possible ideas for seeking biomarkers and precise therapy for the treatment of breast cancer.
作者
缑晓萌
孙洪亮
张中国
薛欣雨
郝景智
张红胜
GOU Xiao-Meng;SUN Hong-Liang;ZHANG Zhong-Guo;XUE Xin-Yu;HAO Jing-Zhi;ZHANG Hong-Sheng(College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2018年第12期1224-1231,共8页
Progress In Biochemistry and Biophysics
基金
生物大分子国家重点实验室开放课题(2017kf02)
2018年国家级大学生创新创业训练计划项目(GJDC-2018-01-52)
北京高等学校高水平人才交叉培养"实培计划"(2017271)资助项目~~
关键词
表观遗传修饰
活性氧
氧化还原状态
乳腺癌
epigenetic modification
reactive oxygen species(ROS)
redox state
breast cancer
