摘要
目的:探讨先天性单纯性腋毛缺失与桥本甲状腺炎(Hashimoto’s thyroiditis,HT)之间的关系。方法:选取116例甲状腺疾病患者,根据是否伴有先天性单纯性腋毛缺失分为2组,其中伴有先天性腋毛缺失的A组52例,男5人,女47人,平均年龄(35.3±11.5)岁,其中HT 46例,Graves病(GD)2例,甲状腺癌(thyroid carcinoma,TC)4例;对照(B)组64例,男26人,女38人,平均年龄(41.4±12.6)岁,其中GD 25例,HT 2例,TC 19例,结节性甲状腺肿(nodular goiter,NG)13例,亚急性甲状腺炎(subacute thyroiditis,ST)5例,对所有患者均进行性毛和甲状腺查体、甲状腺功能和甲状腺自身抗体检测以及甲状腺超声检查。结果:A组伴发HT的概率高达98.06%,而对照组仅为3.13%(P=0.000),且A组55.77%的患者有先天性单纯性腋毛缺失家族史(P=0.000),44.23%的患者有甲状腺疾病家族史(P=0.029),26.54%的患者目前为甲状腺功能减退(P=0.000),94.21%的患者TPOAb和TGAb阳性(均P=0.000)。结论:先天性单纯性腋毛缺失可能作为HT的遗传标志,为早期识别HT患者并及时干预提供临床依据。
Objective:To investigate the association between congenital simple absence of axillary hair and Hashimoto’s thyroiditis (HT). Methods:A total of 116 patients with thyroid diseases were divided into two groups according to the presence or absence of congenital simple absence of axillary hair:52 patients with congenital simple absence of axillary hair as group A and 64 patients without congenital simple absence of axillary hair as group B. In group A,there were 5 male patients and 47 female patients;the mean age was 35.3±11.5 years;there were 46 HT patients,2 Graves’disease(GD)patients,and 4 thyroid carcinoma(TC)patients. In group B,there were 26 male patients and 38 female patients;the mean age was 41.4±12.6 years;there were 25 GD patients,2 HT patients,19 TC patients,13 nodular goiter patients,and 5 subacute thyroiditis patients. All patients underwent physical examination for sex hair and the thyroid,thyroid function test,measurement of thyroid autoimmune antibodies,and thyroid ultrasound. Results:The proportion of HT patients in group A was significantly higher than that in group B(98.06% vs. 3.13%,P=0.000). Among all patients in group A,55.77% had a family history of congenital simple absence of axillary hair,44.23% had a family history of thyroid diseases, 26.54% had hypothyroidism,and 94.21% were positive for thyroid peroxidase antibody thyroglobulin antibody,and these proportions were significantly higher than those in group B(P=0.000,0.029,0.000,0.000,and 0.000). Conclusion:Congenital simple absence of axillary hair may be a genetic marker of HT,thus providing clinical evidence for early identification of HT patients and timely intervention.
作者
刘赫
柴晓峰
连小兰
Liu He;Chai Xiaofeng;Lian Xiaolan(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Science &Peking Union Medical College ,Key Laboratory of Endocrinology of National,Health Commission)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2018年第12期1605-1608,共4页
Journal of Chongqing Medical University
关键词
先天性单纯性腋毛缺失
桥本甲状腺炎
甲状腺自身抗体
congenital simple absence of axillary hair
Hashimoto's thyroiditis
thyroid autoimmune antibodies
