摘要
目的基于关联规则构建慢性阻塞性肺疾病(COPD)急性加重期症状间关联模式。方法采用2006年12月至2008年12月开展的全国9家省级中医院调查所提供的1768份COPD急性加重期患者资料,分为风寒束肺证、外寒内饮证、痰热壅肺证、痰湿阻肺证、痰蒙神窍证、血瘀证,将原始数据进行预处理和数据转换建立基于数据挖掘的数据库。采用Apriori算法,选取最低条件支持度为10%、最小规则置信度为50%、最大前项数为5,对各证候的症状间进行关联规则分析,并构建症状间的网络图。结果风寒束肺证488例,构成症状及舌脉共13个,其频率前3位分别为咳嗽(98. 57%)、喘息(83. 81%)、恶寒(72. 34%);咳嗽和喘息的支持度(83. 811%)及置信度(99. 267%)均为最高。外寒内饮证388例,构成症状及舌脉共16个,其频率前3位分别为咳嗽(99. 23%)、喘息(96. 13%)、恶寒(86. 34%);喘息、咳嗽的支持度最高(86. 911%),气逆不能平卧、胸闷置信度最高(100%)。痰热壅肺证1033例,构成症状及舌脉共14个,其频率前3位分别为咳嗽(99. 23%)、喘息气急(88. 19%)、痰多(79. 57%);喘息气急与咳嗽支持度(88. 190%)、置信度(99. 561%)均为最高。痰湿阻肺证572例,构成症状及舌脉共15个,其频率前3位分别为咳嗽(98. 95%)、痰有泡沫(88. 81%)、气短(86. 88%);喘息、气短支持度最高(84. 441%),口黏腻、食少,纳呆、食少,口黏腻、纳呆、食少置信度最高(100%)。痰蒙神窍证350例,构成症状及舌脉共10个,其频率前3位分别为喘息气促(87. 71%)、神志异常(82. 29%)、喉中痰鸣(73. 71%);神志异常与脉数支持度最高(73. 714%),喘息气促与神志异常置信度最高(75. 740%)。血瘀证642例,构成症状及舌脉共6个,其频率前3位分别为口唇青紫(61. 37%)、舌有瘀斑(41. 9%)、舌下静脉迂曲粗乱(40. 81%);舌质紫暗与舌下静脉迂曲粗乱与舌质黯红与舌有瘀斑的支持度均小于20%,置信度均大于95%。结论应用关
Objective To establish an association pattern between symptoms of acute exacerbation of chronic obstructive pulmonary disease(COPD) based on association rules. Methods The data of 1768 patients with acute exacerbation of COPD provided by the survey of 9 provincial-level Chinese medicine hospitals conducted from December 2006 to December 2008 were used and divided into syndrome of lung tightened by wind-cold,syndrome of external cold and internal fluid,syndrome of phlegm-heat obstructing lung,syndrome of phlegm-dampness blocking lung,syndrome of orifices confused by phlegm and syndrome of blood stasis,and the raw data were pre-processed and dataconverted to establish a database based on data mining. The Apriori algorithm was used to select the minimum conditional support degree of 10%,the minimum rule confidence level of 50%,and the maximum number of front items to be 5,to analyze the association rules between the symptoms of each syndrome,and to construct a network diagram between symptoms. Results There were 488 cases of lung tightened by wind-cold syndrome with 13 symptoms and tongue-pulse diagnoses. The top three frequencies of symptoms were cough(98. 57%),wheezing(83. 81%),and aversion to cold(72. 34%),and the cough and wheezing support rate(83. 811%) and confidence(99. 267%)were the highest. There were 388 cases of external cold and internal fluid syndrome with 16 symptoms and tonguepulse diagnosis. The top three frequencies of symptoms were cough(99. 23%),wheezing(96. 13%),and aversion to cold(86. 34%). The highest support for wheezing and cough(86. 911%),difficult to lie caused by reversed flow of qi and chest congestion were the highest confidence(100%). There were 1033 cases of phlegm-heat obstructing lung syndrome,which consisted of 14 symptoms and tongue-pulse diagnosis. The top three frequencies of symptoms were cough(99. 23%),wheezing urgency(88. 19%),and sputum(79. 57%); wheezing and cough support(88. 190%) and confidence(99. 561%) were the highest. There were 572 cases of phlegm-dampness blocking l
作者
王至婉
闫蔷薇
李建生
陈楚湘
章亮
王翔
WANG Zhiwan;YAN Qiangwe;LI Jiansheng;CHEN Chuxiang;ZHNAG Liang;WANG Xiang(First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhenzhou 450000;Henan University of Chiese Medicine;Information Engineering University of People's Liberation Army;Zhengzhou College of Aeronautical Industry Management)
出处
《中医杂志》
CSCD
北大核心
2018年第24期2120-2125,共6页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81173201)
关键词
慢性阻塞性肺疾病
急性加重期
关联规则
症状关联
症状群
chronic obstructive pulmonary disease
acute exacerbation
association rules
symptom association
symptom group
