血清sFlt-1/PLGF比值与重度子痫前期的相关性及其预测价值研究被引量：10

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摘要目的探讨和研究可溶性血管内皮生长因子受体1(sFlt-1)和胎盘生长因子PLGF水平的比值变化与重度子痫前期发病的相关性及其预测价值,从而对重度子痫前期的诊断和预测提供参考依据。方法应用电化学发光法对临床上诊断为重度子痫前期的56例患者血清标本作为观察组进行sFlt-1和PLGF水平的检测并计算sFlt-1/PLGF比值,成功检测54例标本,其中有2例标本因溶血无法检测。采集24例正常妊娠的孕妇血清标本作为对照组。采集32例未知妊娠结果的孕妇血清标本作为观察组,预测将来子痫前期发病的情况。结果观察组标本血清中sFlt-1水平明显高于对照组(P<0.001),PLGF水平明显低于对照组(P<0.001),sFlt-1/PLGE值显著高于对照组(P<0.001)。观察组采用ROC曲线确定sFlt-1/PLGF比值的截断值,与最终妊娠结果做对比,灵敏度为80.0%,特异度为92.6%,符合率为90.6%。结论可溶性血管内皮生长因子受体1(sFlt-1)和胎盘生长因子PLGF的比值与重度子痫前期的发病有明显的相关性,在预测重度子痫前期发生方面有一定的价值。

作者周伟宁黄演林钟志成骆明勇王挺黄俊

机构地区广东省妇幼保健院产前诊断中心广州医科大学微生物与免疫教研室

出处《中国妇幼保健》 CAS 2018年第23期5394-5396,共3页 Maternal and Child Health Care of China

关键词子痫前期可溶性血管内皮生长因子受体1 胎盘生长因子

分类号 R714 [医药卫生—妇产科学]

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