摘要
目的探讨岩盐气溶胶疗法对尘肺病患者肺功能的影响。方法采用多中心随机对照临床试验研究,选取产煤省份地域、尘肺病患者收治情况有代表性的6家单位于2016年11月—2017年4月收治的452例尘肺病患者为研究对象,随机分为治疗组和对照组,分别在治疗前、治疗后2周、治疗后4周检测尘肺患者每分钟最大通气量(MVV)、用力肺活量(FVC)和最大呼气第1秒呼出的气量容积(FEV1),采用SPSS20.0对结果进行统计学分析。结果①两组患者治疗后MVV和FVC及1秒率(FEV1/FVC)均有所提升,岩盐治疗组治疗前后差异有统计学意义(P<0.05);治疗后各时点患者MVV、FVC改善程度,治疗组均大于对照组,差异有统计学意义(P<0.05);治疗后各时点患者FEV1/FVC改善程度差异无统计学意义(P>0.05)。②两组各期别尘肺病患者MVV治疗后均呈升高趋势,治疗组升高的程度大于对照组,其中壹期(治疗后2周、4周)、贰期(治疗后4周)和叁期(治疗后2、4周)差异有统计学意义(P<0.05);两组各期别尘肺病患者FVC治疗后均呈升高趋势,但治疗组升高的程度大于对照组,其中壹期(治疗后4周)、贰期和叁期差异有统计学意义(P<0.05);③合并慢性阻塞性肺疾病(COPD)治疗组与合并COPD对照组比较,MVV升高,差异有统计学意义(P<0.05);单纯治疗组与单纯对照组(治疗后2周)相比,MVV变化差异有统计学意义;合并COPD治疗组与合并COPD对照组比较,FVC升高,差异有统计学意义(P<0.05);单纯治疗组与单纯对照组治疗后4周相比,盐岩气溶胶治疗后FVC变化差异有统计学意义(P<0.05)。结论在常规治疗基础上,岩盐气溶胶疗法可以即时性提高MVV和FVC。
[Objective]To explore the effects of halotherapy on pulmonary function of pneumoconiosis patients.[Methods]Through a method of the randomized multi-center clinical study,452 cases of pneumoconiosis patients were collected from six hospitals which are in coal producing provinces and have representativeness of therapeutic characteristics of pneumoconiosis from from November 2016 to April 2017,which were randomly divided into treatment group and control group. The maximal voluntary ventilation (MVV), forced vital capacity(FVC) and the first second forced expiratory volume(FEV1) were tested before treatment,two weeks and four weeks after treatment,and the results were analyzed statistically.[Results]①The levels of MVV,FVC and FEV1/FVC in two groups increased after treatment,and the differences in treatment group was statistically significant between before and after treatment. At all time-points after the treatment,the improvement levels of MVV and FVC in treatment group were higher than those in control group, and the differences were statistically significant. There was no statistically significant difference in improvement level of FEV1/FVC at all time-points after the treatment. ②After treatment,the level of MVV in patients at different stage increased in both two groups, and the improvement level in treatment group was higher than that in control group,while the differences were statistically significant in stage Ⅰ (two and four weeks after treatment ) and stage Ⅱ (four weeks after treatment ) ,stage Ⅲ (two and four weeks after treatment). After treatment,the level of FVC in patients at different stage increased in both two groups,and the improvement level in treatment group was higher than that in control group,while the differences were statistically significant in stage Ⅰ (four weeks after treatment),stage Ⅱ and stage Ⅲ(P<0.05). ③The level of MVV in treatment group combined with chronic obstructive pulmonary disease(COPD) was higher than that in control group combined with COPD,and the diffe
作者
孙志谦
袁扬
段建勇
李姝华
刘红梅
张木子
朱丽
陈刚
SUN Zhi-qian;YUAN Yang;DUAN Jian-yong;LI Shu-hua;LIU Hong-mei;ZHANG Mu-zi;ZHU Li;CHEN Gang(Medical Department,Beidaihe Sanatorium for Chinese Coal Miners,Qinhuangdao Hebei,066100,China)
出处
《职业与健康》
CAS
2018年第23期3190-3194,3202,共6页
Occupation and Health
基金
中国煤矿尘肺病防治基金会项目(2016-01-01总J024)
关键词
岩盐气溶胶
尘肺病
肺功能
Rock salt aerosol
Pneumoconiosis
Pulmonary function
