摘要
目的观察利福霉素注射液联合头孢噻肟钠注射剂治疗化脓性脑膜炎的临床疗效及安全性。方法将96例化脓性脑膜炎患儿随机分为对照组和试验组,每组48例。对照组予以头孢噻肟钠每次75 mg·kg^(-1),bid,静脉滴注,持续治疗14 d;试验组在对照组治疗的基础上,予以利福霉素每次15 mg·kg^(-1),qd,静脉滴注,持续治疗7～10 d。比较2组患儿的临床疗效,血清C反应蛋白(CRP)和乳酸脱氢酶(LDH)、神经元烯醇化酶(NSE)水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93. 75%(45例/48例)和75. 00%(36例/48例),差异有统计学意义(P <0. 05)。治疗后,试验组和对照组的血清CRP水平分别为(27. 89±4. 30)和(42. 86±4. 54) mg·L^(-1),LDH水平分别为(25. 18±3. 40)和(57. 92±6. 82) U·L^(-1),NSE水平分别为(33. 59±6. 15)和(63. 98±8. 73)μg·L^(-1),差异均有统计学意义(均P <0. 05)。2组患儿的药物不良反应均以胃肠道反应、头晕和皮疹为主,试验组和对照组的总药物不良反应发生率分别为18. 75%和14. 58%,差异无统计学意义(P> 0. 05)。结论利福霉素注射液联合头孢噻肟钠注射剂治疗化脓性脑膜炎的临床疗效显著优于单用头孢噻肟钠注射剂,其能有效地降低血清CRP、LDH和NSE水平,且不增加药物不良反应的发生率。
Objective To observe the clinical efficacy and safety of rifamycin injection combined with cefotaxime sodium injection in the treatment of purulent meningitis.Methods A total of 96 patients with pediatric purulent meningitis were divided into control group and treatment group with 48 cases per group.Control group was treated with cefotaxime sodium 75 mg·kg^-1 per time,bid,intravenous drip,continuous treatment of 14 d.Treatment group was given rifamycin 15 mg·kg^-1 per time,qd,intravenous drip,continuous treatment of 7 - 10 d,on the basis of control group.The clinical efficacy,serum levels of C - reactive protein (CRP) ,lactate dehydrogenase (LDH) and neurons enolization enzyme (NSE) ,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 93.75% (45 cases /48 cases) and 75.00% (36 cases /48 cases) with significant difference (P<0.05) .After treatment, the main indexes of treatment and control groups were compared: serum CRP were (27.89±4.30) and (42.86±4.54) mg·L^-1,LDH were (25.18±3.40) and (57.92±6.82) U·L^-1, NSE were (33.59±6.15) and (63.98±8.73) μg·L^-1,and the differences were statistically significant (all P<0.05) .Adverse drug reactions of two groups were gastrointestinal reactions,dizziness and rash.The total incidences of adverse drug reactions in control and treatment groups were 18.75% and 14.58% without significant difference (P > 0.05) .Conclusion Rifamycin injection combined with cefotaxime sodium injection has a definitive clinical efficacy in the treatment of purulent meningitis,and better than cefotaxime sodium inyection only,which can significantly reduce the levels of CRP,LDH and NSE,without increasing the incidence of adverse drug reactions.
作者
李国庆
LI Guo - qing(Department of Pediatrics, The Third People's Hospital of Jinan, Jinan 250132,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2018年第23期2683-2685,2689,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81273703)
