摘要
目的探讨血清可溶性血管黏附因子1(soluble vasccular cell adhension molecule-1,sVCAM-1)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平变化与冠心病患者核转录因子-KB(nuclear transcription factor-KB,NF-KB)的相关性。方法选取2016年9月至2017年9月期间我院收治的130例冠心病患者临床资料进行前瞻性研究,选取同期进行体检的健康人50例作为对照组。比较各组间基本资料、生化指标,并进行Spearman相关分析与Logistic多元回归相关分析。结果冠心病组吸烟史、高血压史、糖尿病史、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、sVCAM-1、TNF-α、NF-KB均显著高于对照组,HDL-C显著低于对照组(P<0.05)。急性心肌梗死(acute myocardial infarction,AMI)组血清sVCAM-1、TNF-α、NF-κB水平显著高于稳定型心绞痛(stable angina pectoris,SAP)组和不稳定型心绞痛(unstable angina pectoris,UAP)组,HDL-C显著低于SAP组和UAP组(P <0.05);UAP组血清sVCAM-1、TNF-α、NF-κB水平显著高于SAP组(P <0.05),而两组HDL-C无统计学差异(P>0.05)。经过Pearson相关性分析,sVCAM-1、TNF-α与冠心病患者NF-KB呈正相关,HDL-C与冠心病患者NF-κB呈负相关。经过多元回归分析,sVCAM-1、TNF-α、NF-KB是冠心病的独立危险因素,HDL-C是保护因素。结论 sVCAM-1、TNF-α、HDL-C及NF-κB均与冠心病的发生、发展有密切关系,其中NF-κB作为引发炎症的关键转录因子,可能对sVCAM-1、TNF-α、HDL-C的表达产生调节作用,共同影响冠心病的发展。
Objective To investigate the correlation between serum sVCAM-1,TNF-a,HDL-C and NF-κB in patients with coronary heart disease. Methods The clinical data of 130 patients with coronary heart disease from September 2016 to September 2017 in our hospital were studied prospectively. The basic data,biochemical indexes,Spearman correlation analysis and Logistic multivariate regression analysis were carried out in all patients and 50 healthy persons who were examined in the same period as control group. Results The history of smoking,hypertension,diabetes,TG、LDL-C、sVCAM-1、TNF-α、NF-κB in the CHD group were significantly higher than those in the control group, and HDL-C was significantly lower than that in control group(P<0.05). The levels of serum sVCAM-1,TNF-α,NF-κB in AMI group were significantly higher than those in SAP group and UAP group(P <0.05). The levels of serum sVCAM-1,TNF-a,NF-κB in UAP group were significantly higher than those in SAP group(P < 0. 05), but there was no significant difference in HDL-C between the two groups( P > 0. 05). After pearson correlation analysis,there was a positive correlation between sVCAM-1,TNF-a and NF-κB in patients with coronary heart disease. HDL-C was negatively correlated with NF-κB in patients with coronary heart disease. Multivariate regression analysis showed that sVCAM-1, TNF-a and NF-κB were independent risk factors of coronary heart disease, and HDL-C was protective factor. Conclusion sVCAM-1,TNF-a,HDL-C and NF-κB are closely related to the occurrence and development of coronary heart disease, among which NF-κB is the key transcription factor to trigger inflammation. It may regulate the expression of sVCAM-1, TNF-α, HDL-C and affect the development of coronary heart disease.
作者
崔翔
CUI Xiang(Department of Laboratory,Haian Hospital Affitiated Nantong University,Haian 226600,China)
出处
《标记免疫分析与临床》
CAS
2018年第11期1611-1614,共4页
Labeled Immunoassays and Clinical Medicine
