摘要
目的:研究银翘散常压煎药机最佳煎煮工艺。方法:本试验以绿原酸、牛蒡苷、连翘苷、芦丁、橙皮苷,合煎液中浸出物与相对密度为指标,采用单因素考察和正交试验相结合的方法,选择浸泡时间、加水量、煎煮时间、煎煮次数4个因素,每个因素选取3个水平进行正交试验。结果:浸泡时间、加水量、煎煮时间对检测指标具有显著性影响。银翘散常压煎药机最佳煎煮工艺为A1B3C3D2组合,即将银翘散饮片浸泡15min,一煎加16倍水,二煎加10倍水,煎煮2次,每次常压煎药机煎煮25min。结论:本研究通过单因素考察与正交试验优选银翘散最佳常压机器煎煮工艺,对规范中药汤剂煎煮工艺具有积极意义。
Objective:To research the best decoction process for Yinqiao Powder with atmospheric machine.Methods: Taking leachate of decoction,including Chlorogenic acid,Rutin,Hesperidin,Arctinin,and Phillyrin,and relative density as index, this test selects four factors such as soaking time,water addition,boiling time and boiling times,each factor selects three levels for orthogonal experiment by the method of single factor investigation combined with orthogonal test.Results:Soaking time, water addition and boiling time have significant influence to detection index.The best decoction process for Yinqiao Powder is combination of A1B3C3D2 with atmospheric machine,as soaking the decoction pieces of Yinqiao Powder for 15 mins,decoction with 16 times the amount of water for the first time,the second decoction with 10 times,and decocting 2 times for 25 min every time with atmospheric machine.Conclusion:The best decoction process for Yinqiao Powder is selected based on single factor test and orthogonal tese,which has positive significance for standardizing the decoction process.
作者
束雅春
陆兔林
秦昆明
陈亚军
蔡宝昌
SHU Ya-chun;LU Tu-lin;QIN Kun-ming;CHEN Ya-jun;CAI Bao-chang(Affiliated Hospltal of Nan ling University of Chinese Medicine,Nanjing 210029,China;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine,Nanjing 210046,China;Nanjing Haichang Chinese Medicine Group Co.,Ltd.,Nanjing 210061,China;Women's Hospital of Nanjing Medical University,Nanjing 210004,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2018年第12期5568-5572,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81503216)
2016年江苏省高层次卫生人才"六个一工程"科研项目(No.LGY2016017)
江苏省六大人才高峰第9批项目(No.WS-029)
全国首批中药特色技术传承人才项目
第五批南京市科技发展计划国际联合研发项目(No.20160508)~~
关键词
正交试验
银翘散
煎煮工艺
绿原酸
芦丁
牛蒡苷
连翘苷
橙皮苷
Orthogonal experiments
Yinqiao Powder,Decoction process
Chlorogenic acid
Rutin
Arctinin
Phillyrin
Hespetidin
