摘要
目的探讨大肠癌组织中细胞外基质金属蛋白酶诱导因子 (extracellularmatrixmetalloproteinaseinduc er,EMMPRIN)的表达与肿瘤病理类型和转移方式的关系。 方法免疫组化方法检测 4 0例正常组织和 4 0例大肠癌组织中EMMPRIN的表达、病理类型和转移方式 ,并加以分析。 结果 4 0例大肠癌标本中有 2 8例呈阳性表达 ,阳性率为 70 % ;而 4 0例对照组中只有 2例呈阳性表达 ,阳性率为 0 .0 5 %。 结论EMMPRIN表达与大肠肿瘤的病理类型、转移方式相关 ,在未分化癌中有显著高表达 。
Objective To analyze the relationship of extracellular matrix metalloproteinase inducer (EMMPRIN) and the type of tumor pathology and the ways of metastasis. Methods The expression of EMMPRIN in 40 human normal colorectal tissues and cancer tissues of 40 patient with colorectal cancer was examined by an immunohistochemistry method, and the type of tumor pathology and metastasis was analyzed to find the relationship of them. Results Twenty-eight of the 40 patients showed positive expression (70%). In the control group only 2 cases had positive expression (0.05%). Conclusion The expression of EMMPRIN has relation with the pathological type, blood and lymph metastasis. EMMPRIN is highly expressed in patients with non-differentiated cancer; this is also with blood and lymph metastasis.
出处
《上海第二医科大学学报》
CSCD
2002年第2期115-117,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
上海市教委基金资助项目 (98QN62 )
关键词
大肠癌
细胞外基质金属蛋白酶
肿瘤浸润
肿瘤转移
colorectal cancer
extracellular matrix metalloproteinase
infiltration
metastasis
