摘要
目的 探讨 99m Tc羟基亚甲二磷酸 (MDP) SPECT显像 (MDPSI)、CT、纤支镜 (FB)和肿瘤标志物 (TM)检查诊断肺癌的临床价值。方法 对 6 3例经病理证实的肺肿瘤患者和 10例正常对照进行早期 (5 min) MDPSI,CT、FB和TM检查 ,以病理为标准比较分析诊断效能。结果 肺癌对99m Tc MDP的摄取明显高于良性病灶和正常对照 ,以摄取比值 >1.8为判断标准 ,MDPSI诊断肺癌的灵敏度、特异性和准确率分别为 90 .2 %、90 .9%和 90 .4 % ;CT、FB和 TM分别为 92 .2 %、6 3.6 %和 83.6 %、6 3.9%、10 0 %和 6 9.0 %、6 6 .7%、6 8.2 %和 6 7.1% ;MDPSI和 CT联合诊断肺癌的灵敏度、特异性和准确率分别为 96 .1%、95 .5 %和 95 .9%。结论 MDPSI对肺癌的诊断有较高的临床价值 ,与
Objective To investigate the clinical significance of 99m Tc MDP SPECT imaging(MDPSI),X CT,fibro optic bronchoscope(FB) and tumor marker(TM) in diagnosing patients with lung neoplasms.Methods MDPSI,XCT,FB and TM detection were performed on 63 patients with pulmonary neoplasms confirmed by pathology and 10 healthy subjects.SPECT data was acquired 5 minutes after injection of 1110MBq 99m Tc MDP.The diagnostic efficacy was compared according to pathological standards.Results The uptake of 99m Tc MDP in malignant lesions(2.36± 0.56 ) was significantly higher than benign ones(1.44±0.47) and normal ones( 0.98 ±0.12)(t=5.26,7.70,P<0.01).When the uptake was 1.80 as threshold,the sensitivity,specificity and overall accuracy of MDPSI in diagnosis of lung neoplasms was 90.2%,90.9% and 90.4% respectively;X CT was 92.2%,63.6% and 83.6%,FB 63.9%,100% and 69.0% ,TM 66.7%,68.2% and 67.1% respectively.The sensitivity,specficity and overall accurancy of MDPSI combined with X CT in diagnosis of lung neoplasms was 96.1%,95.5% and 95.9% respectively.Conclusion 99m Tc MDP was valuable in diagnosing lung neoplasms and its combination with X CT should further improve the diagnostic accuracy of lung neoplasms.
出处
《中国误诊学杂志》
CAS
2002年第3期335-337,共3页
Chinese Journal of Misdiagnostics
